ID A0A1M5VPF8_9CLOT Unreviewed; 889 AA.
AC A0A1M5VPF8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN02745207_02414 {ECO:0000313|EMBL:SHH77115.1};
OS Clostridium grantii DSM 8605.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121316 {ECO:0000313|EMBL:SHH77115.1, ECO:0000313|Proteomes:UP000184447};
RN [1] {ECO:0000313|EMBL:SHH77115.1, ECO:0000313|Proteomes:UP000184447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8605 {ECO:0000313|EMBL:SHH77115.1,
RC ECO:0000313|Proteomes:UP000184447};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FQXM01000012; SHH77115.1; -; Genomic_DNA.
DR RefSeq; WP_073338674.1; NZ_FQXM01000012.1.
DR AlphaFoldDB; A0A1M5VPF8; -.
DR STRING; 1121316.SAMN02745207_02414; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000184447; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000184447}.
FT DOMAIN 688..704
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 889 AA; 100844 MW; 22DC2568DD6396DE CRC64;
MALTPMMQQY LQIKENYKDC ILFFRLGDFY EMFFEDAEIV SRELELVLTG KSCGLEERAP
MCGIPYHASN SYLIRLVNKG YKIAVCEQLE DASATKGIVK RDVVKVVTPG TYTDSSFLDE
KKNNFIMSIY LKESKGALCF ADLSTGEFYG TSIFNDEAVI LDEISKFLPS EILIYEEIDK
TLISSIKERF NTSFTSVKSE NLLNTSSLKI KEQFKNYDEN NFDEHLVISS NVLLSYINET
QKSVLGHVDY FTYYQVEDFL GIDINSRRNL ELTESLRDKR KKGSLLWVLD KTKTAMGARM
LRKWVEQPLI VEGSINNRLN AIEELTMNMP LLDELRDELN KIYDIERLIG KISGKNVNAK
ELVSLQNSLL NLPYIKKLLS NTESDLLNNT YKEIDTLEDI HSFLFSSLLE NPAISVKEGG
IIKDGYNEEV DELRKAKAHG KEWIAALESR EKDLTGIKSL KIRYNKVFGY YIEVTKLNME
FVPKDRYTRK QTLANAERYV TDELKEMEEK ILGAEEKLTT LEYEIFVQIR DVIESHIDRM
KKTSNFLSSL DCLCSLAMCA IENNYVKPII TKDNKISIKE GRHPVVEKVI QREGFISNDT
IIDDKDNNLL LITGPNMAGK STYMRQVALI TVMAQIGSFV PAKEASISIC DKVFTRIGAS
DDLAGGKSTF MVEMWEVANI LKNSTKESLI LLDEVGRGTS TYDGLSIAWA VIEFICENKS
SKAKTLFATH YHELTSLEGK ISGVQNYSIA VKKLKDDIVF LRKIIKGSAD DSYGIEVAKL
AGIPEQVTNR AKEILVILEK GGVNTSEVSY TIVDSINAKE EVSSIEVVKE KSKKNIKEVR
QTEQMQLGFA DLEKEKLIAE ISNIDIINLT PMDSLNKLYD IIKKAKTII
//
