ID A0A1M5XDR3_9ACTN Unreviewed; 488 AA.
AC A0A1M5XDR3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN05444521_2986 {ECO:0000313|EMBL:SHH97634.1};
OS Streptomyces sp. 3214.6.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1882757 {ECO:0000313|EMBL:SHH97634.1, ECO:0000313|Proteomes:UP000190947};
RN [1] {ECO:0000313|Proteomes:UP000190947}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3124.6 {ECO:0000313|Proteomes:UP000190947};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LT670819; SHH97634.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M5XDR3; -.
DR STRING; 1882757.SAMN05444521_2986; -.
DR Proteomes; UP000190947; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.280; GAF domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR038424; H_kinase_PdtaS_GAF_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR022066; PdtaS_GAF.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF23; SENSOR HISTIDINE KINASE PDTAS-RELATED; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07568; HisKA_2; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF12282; PdtaS_GAF; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SHH97634.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000190947};
KW Transferase {ECO:0000313|EMBL:SHH97634.1}.
FT DOMAIN 290..486
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 488 AA; 53601 MW; B3133814FF9EE885 CRC64;
MNELVRQHTA LDDSDLEWLH LLVSEWQLLS DLSFADLVLW VPTRDGARYV SVAQMRPNTG
PTSYQDDMVG HLVPRGRRPL LDAALDEGRI VREGDPEWRE EVPVRVESIP VRREGRVLGV
IARNTNLLTV RTPSRLELTY LQSASDLAQM IAAGSFPFPN QLMDMDAAPR VGDGLIRVDG
EGIVQYASPN ALSAYHRMGL ASDLVGQHLG LTTAELAPTR GPVDEALAKV ASGWAPREFE
IEANDGVIQF RAIPLKPKGT RIGALVLLRD VTELRRRERE LITKDATIRE IHHRVKNNLQ
TVAALLRLQA RRIESERGRE ALEEAVRRVG SIAIVHETLS QNLDERVEFD EIADRVLAMV
AEISPGKVTG RRSGRFGILD AEVATPLSMV LTEILQNALE HGFREGDTGT VEVSAVRGGT
TKEGRLLVTV QDDGVGLPEG FDPHTSGNLG LQIVRTLVEG ELGGTFDMVP APEHGTQVIL
DIPVAAQK
//
