ID A0A1M5XJ76_9FIRM Unreviewed; 517 AA.
AC A0A1M5XJ76;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=H+/Cl-antiporter ClcA {ECO:0000313|EMBL:SHH99598.1};
GN ORFNames=SAMN02745823_01847 {ECO:0000313|EMBL:SHH99598.1};
OS Sporobacter termitidis DSM 10068.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Sporobacter.
OX NCBI_TaxID=1123282 {ECO:0000313|EMBL:SHH99598.1, ECO:0000313|Proteomes:UP000183995};
RN [1] {ECO:0000313|EMBL:SHH99598.1, ECO:0000313|Proteomes:UP000183995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10068 {ECO:0000313|EMBL:SHH99598.1,
RC ECO:0000313|Proteomes:UP000183995};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FQXV01000005; SHH99598.1; -; Genomic_DNA.
DR RefSeq; WP_073078000.1; NZ_FQXV01000005.1.
DR AlphaFoldDB; A0A1M5XJ76; -.
DR STRING; 1123282.SAMN02745823_01847; -.
DR OrthoDB; 9812438at2; -.
DR Proteomes; UP000183995; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR CDD; cd01031; EriC; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000183995};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 428..510
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 517 AA; 54610 MW; D76253332634755F CRC64;
MIKSKVHEIL SELNQLKWSG AVKGILVGLI SGLLVVLYRL GIEYGYASSV RIFSYLRLHP
LAIVPWVGAA VGLGLFIAWL VKKEPMASGS GIPQVEGQVL YGLRLKWYSI LAVRFIAGLM
SSLFGVSLGR EGPSIQIGAS GGQAVAKKIS RNKLEENYLI TGGAAAGLAA AFNAPLSGIV
FALEEVHRSF SPLILIAATT ASLTADVVSK YFFGLTPVLD FRTVPQLPEA QYFWLIPLGI
LAGLVGALLN KSLLRFQLLY RRLPRFMGPA AALLLTLPCG LFLPQILGGG ANLINIAENV
SSGAVILLVF AVTKLVFTCT SFGSGIPGGI FMPILSVGAL SGSLFGMACT HLGLPPAYIA
DFAVCGMAGA LSGSVKAPIT SILLTAEMTG SLVHLLPVAA CSFVALFVSD FLKVTPIYEA
LLERIIETNE DTIKNDKVGG LVEIPVELGC AAAGKRIGDI DLPEGTLIVN IHRGSKDIVP
GQNTVIAPGD YLVLLSSESS YADLHLRVRE LCHSNAK
//
