ID   A0A1M5Z4R2_9ACTN        Unreviewed;       738 AA.
AC   A0A1M5Z4R2;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SHI19265.1};
GN   ORFNames=SAMN05444521_5120 {ECO:0000313|EMBL:SHI19265.1};
OS   Streptomyces sp. 3214.6.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1882757 {ECO:0000313|EMBL:SHI19265.1, ECO:0000313|Proteomes:UP000190947};
RN   [1] {ECO:0000313|Proteomes:UP000190947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3124.6 {ECO:0000313|Proteomes:UP000190947};
RA   Varghese N., Submissions S.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; LT670819; SHI19265.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M5Z4R2; -.
DR   STRING; 1882757.SAMN05444521_5120; -.
DR   Proteomes; UP000190947; Chromosome i.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190947};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        174..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        305..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        523..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        580..600
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        621..649
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        655..678
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          198..330
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          701..738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..738
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   738 AA;  76333 MW;  41160A16B3160B48 CRC64;
     MMRTMASLPS GRVTKWVVLA LWAALLVPAV LLAGRLGDVE ENDNSAWLPG NAESTEVVER
     AERFRPDDTV PAIVIYDRPG GVTPADLSKA RADAEAFKGV ENVVGQPQGP VTSQDGEAVQ
     TVVQVHKDRT GWEGIGKVVD ALTEVGEKNA DGLGFHVTGP AGHASDSIKA FSSGGSLTAI
     TASVVVVILL LTYRSPVLPL LPLLTVGGAL VTSEAAIYLL AKNAGLTVNK QTGFILTVLV
     FGAATDYALL LTSRYREELR RHADRHEAMA QALYRSGPAI LASAATVAVS LTLLMLATLN
     STQGLGPACA VGILVGFLAM VTLMPALLVI CGRWIFWPVR PAQGAAGEGA DGAGGADGGV
     WTRVGTAVSG RPRLVWIGAA LALGVMAVGV FGLKADGLSS KDQFTGTPQT AVGEEIQARH
     FPAGSGDPVY VVARAASAEQ AERVRAALAD VPGVAAVSTP TLKDGDALML GELADDPSST
     AAMRTVEQAR TAVHAVEGAD AQVGGTTAVA LDTQQAAARD SEVIIPIVLL VVFLVLALLL
     RALVAPLLLM ATVVLSFGAA LGVSSLMFDH VFGFAGAEAS FPLLTFVFLV ALGIDYNIFL
     VTRVREEALL HGTRRGALTG LSATGGVITS AGLVLAGTFA AMASLPLVFA AELGFAVAFG
     VLLDTLVVRS VLVTALTLDV GRWMWWPSSL FRRHDAYAAE RATSSGWKKP VSDGARHSGA
     TNPASATSPA SRSRPSAQ
//