ID A0A1M5ZWN5_9ACTN Unreviewed; 840 AA.
AC A0A1M5ZWN5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits {ECO:0000313|EMBL:SHI28707.1};
GN ORFNames=SAMN05444521_6968 {ECO:0000313|EMBL:SHI28707.1};
OS Streptomyces sp. 3214.6.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1882757 {ECO:0000313|EMBL:SHI28707.1, ECO:0000313|Proteomes:UP000190947};
RN [1] {ECO:0000313|Proteomes:UP000190947}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3124.6 {ECO:0000313|Proteomes:UP000190947};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LT670819; SHI28707.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M5ZWN5; -.
DR STRING; 1882757.SAMN05444521_6968; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000190947; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03213; ABCG_EPDR; 1.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR48041:SF91; ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A; 1.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF00498; FHA; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00240; FHA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000190947};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 617..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..70
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 183..233
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 265..506
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 102..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 90876 MW; 5E108D78448A15F2 CRC64;
MPELVLELNG RTWTLDPSRT YALGRDPQGD IVLDDARVSW RHATVSFNGR SWVVEDHGST
NGTFAQGQRV HQLELGPGSV LHLGNATDGP RVDLTGAQAP VAQPQQQPFA AQAANPGWAQ
QAPQPQAAQA GWQQPQQAAP QVPQQGPAAG YAQNVPGGGA GAPPVYGDRS PTTFHHFSLG
RVMRIGRALE NELVVSDLQV SRHHAEFHST PDGRMEIRDL GSHNGTYVNG QPIPKGGSVQ
LGPADIVGVG HSTFRIVGDR LEEFVDTGEV SFSARHLTVT VDGGKQILKD VSFGVPEKSL
IAVIGPSGSG KSTLLKALTG YRPANQGDVL YDNRNLYKQF AELRQRIGLV PQDDILHKEL
TVKKALKYAA KLRFPADTTP AERDTRIDEV LRELKLDIHK EKKVTSLSGG QRKRVSVALE
LLTKPSLIFL DEPTSGLDPG MDRDVMQLLR GLADDGRTVL VVTHSVAELA ICDKLLVMAP
GGAVAYFGPP EEALNFFGYD TWADVFSAFE NYRDYDWAGR WKGSQHYQMY AADIDAIAPQ
SVQMPPMQAM KPPKPQGWMS QFVTLVRRYV SVIASDKGFL ALTVILPAVL GAVSLLIDSG
NSLLPNPVNP KSGRIIPNGT ATTVLLILAV GACFAGAANS VRELIKERVI YERERATGLS
RSAYLMSKVF VLGVVTVLQG LMVGVIGFAS REIPKEGLVL GSATMFELSI PIMALGFTSM
MFGLVISSLV KTAEKTMPLL VMFAIIQVVF TGCLFTLNGA VGVNQFSYLM PSRWAVAAAG
ATLDFNKISP PKDGGETDPL WEHTVGAWGM DMAALIVLGV ICGFFVARFL RRHEPEVMRK
//
