ID A0A1M6A9P5_9BACT Unreviewed; 623 AA.
AC A0A1M6A9P5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Zn-dependent protease with chaperone function {ECO:0000313|EMBL:SHI33181.1};
GN ORFNames=SAMN02745146_0557 {ECO:0000313|EMBL:SHI33181.1};
OS Hymenobacter daecheongensis DSM 21074.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1121955 {ECO:0000313|EMBL:SHI33181.1, ECO:0000313|Proteomes:UP000184418};
RN [1] {ECO:0000313|EMBL:SHI33181.1, ECO:0000313|Proteomes:UP000184418}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21074 {ECO:0000313|EMBL:SHI33181.1,
RC ECO:0000313|Proteomes:UP000184418};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FQYN01000001; SHI33181.1; -; Genomic_DNA.
DR RefSeq; WP_073104997.1; NZ_FQYN01000001.1.
DR AlphaFoldDB; A0A1M6A9P5; -.
DR STRING; 1121955.SAMN02745146_0557; -.
DR OrthoDB; 9789270at2; -.
DR Proteomes; UP000184418; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07328; M48_Ste24p_like; 1.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR InterPro; IPR001915; Peptidase_M48.
DR PANTHER; PTHR43221; PROTEASE HTPX; 1.
DR PANTHER; PTHR43221:SF1; PROTEASE HTPX; 1.
DR Pfam; PF01435; Peptidase_M48; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SHI33181.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000184418};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 28..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..331
FT /note="Peptidase M48"
FT /evidence="ECO:0000259|Pfam:PF01435"
SQ SEQUENCE 623 AA; 68558 MW; 9794573B4F6C7409 CRC64;
MTREEFLARL RRLSPLAEAN PAGYRRRVWL WALLGYAGIL LLLLGTVGLL LLTLAVGVFS
KAFAIVFKVG AVLAVFAWKV LRSLWVKFDP PEGLPLTPAE AAPLLALLQQ QTQALRAPQV
HQVLLTADFN AAAVQVPRLG VLGWPRNYVV VGLPLLQSLS PVQAAAVVGH ELGHLRGGHG
RFGAWIYRVS QTWTQLIEQL ERQSNRSLFS RFTAWYVPRF NAWSHPVRRT DEFAADAAAA
QLTSPQAMAE ALCATVVRDA TLDRLHWNVL SASLAERPTP PSDAISRLLP LAKNSRLPAA
DEQILLANAN EAEPDLFSTH PTLGERLAAL GQAAAVPPLP ATTAAEAWLG ASLPALAAAL
DEAWVSSRAA IWQERHSLLR QQQERLRELT TQQQAGASLT ADESWELADL TEDHISSTEA
LPLFQQLTDD ARWKLPARFS VGRILLNSDN AEGLTWLAAV MEQEPNYMAP GLALQEAYYQ
RQGNREQVRK LGAVQLRHAD TLDEAVAERE AIRPADTLLP HGLTEEELQK LRAELAVPEY
AIGRAWLMRK QVQYFIQKPL YVLLVARLST AAGSSKEAPE TWVQELAAKI ELPGEGFVIA
IGKDFAWLER AARQQAAAEV FVA
//
