ID A0A1M6CHN8_9FLAO Unreviewed; 443 AA.
AC A0A1M6CHN8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=SAMN05216261_1255 {ECO:0000313|EMBL:SHI60433.1};
OS Algibacter luteus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Algibacter.
OX NCBI_TaxID=1178825 {ECO:0000313|EMBL:SHI60433.1, ECO:0000313|Proteomes:UP000184396};
RN [1] {ECO:0000313|EMBL:SHI60433.1, ECO:0000313|Proteomes:UP000184396}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.12213 {ECO:0000313|EMBL:SHI60433.1,
RC ECO:0000313|Proteomes:UP000184396};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; FQYK01000002; SHI60433.1; -; Genomic_DNA.
DR RefSeq; WP_026010025.1; NZ_FQYK01000002.1.
DR AlphaFoldDB; A0A1M6CHN8; -.
DR STRING; 1178825.SAMN05216261_1255; -.
DR eggNOG; COG0508; Bacteria.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000184396; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Reference proteome {ECO:0000313|Proteomes:UP000184396};
KW Transferase {ECO:0000256|RuleBase:RU003423, ECO:0000313|EMBL:SHI60433.1}.
FT DOMAIN 3..78
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 127..167
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 443 AA; 48498 MW; B8B2E68A7C0D981B CRC64;
MAKFELKLPK MGESVAEATI TSWLKNVGDT IEMDDPVLEI ATDKVDSEVP SEVDGVLVER
FFNVDDVVQV GQVLAIIETE GDETDEAEES TKVEEEIVPE VAVQEIEETI TKAKETVAPA
VSTSDRFYSP LVKNIAKAEG VSQAELDQIS GTGKDGRVTK NDILDYIKNK GSQQQPAATK
SQPTVASVAP VNTESLPKQD KPVVVSNGED EIIEMTRMGK LIAHHMVESV QTSAHVQSFI
EADVTNIWNW RKKVKDAFMK REGENLTFTP IFMEAIAKAL RDYPMMNISV QGDKIIKKKN
INLGMAAALP DGNLIVPVIK NADQLNLVGM TKQVNDLANR ARIGKLKPDD TQGGTYTVTN
VGTFGSIMGT PIINQPQVGI LALGAIRKVP AVIETPEGDF IGIRYKMFLS HSYDHRVVNG
ALGGQFVKAV TDYLEAWDMN REI
//
