ID A0A1M6E273_9ACTN Unreviewed; 685 AA.
AC A0A1M6E273;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=SAMN02745244_01080 {ECO:0000313|EMBL:SHI79586.1};
OS Tessaracoccus bendigoensis DSM 12906.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Tessaracoccus.
OX NCBI_TaxID=1123357 {ECO:0000313|EMBL:SHI79586.1, ECO:0000313|Proteomes:UP000184512};
RN [1] {ECO:0000313|EMBL:SHI79586.1, ECO:0000313|Proteomes:UP000184512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12906 {ECO:0000313|EMBL:SHI79586.1,
RC ECO:0000313|Proteomes:UP000184512};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; FQZG01000015; SHI79586.1; -; Genomic_DNA.
DR RefSeq; WP_073186518.1; NZ_FQZG01000015.1.
DR AlphaFoldDB; A0A1M6E273; -.
DR STRING; 1123357.SAMN02745244_01080; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000184512; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184512};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..327
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 409..670
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 685 AA; 74082 MW; 8F2857D0C63D792E CRC64;
MRTLAEHITR HHRLLLVVFG ALTAVCGFLT LLVPINYNLA DFIPPEAPSK VATDVMAQEF
DDSIPNVRVF VPGLSLSEAV ETRQQIEEVP AVQSMLWLDD LVDLKTPLEL QDQSLVSGFQ
TDAGSLFQVS VALDDTVATL AQLQEIATPD GAVEGQLVDL ALAQQSTTSE VGTIVVFMVP
LALGLLILST LSWLEPVVLM ATIGVAVVLN MGTNIFVGEI SFITAAVAGV LQFAVSMDYG
IFLLHAQKRH LEAGEGRLKA LQSAVVDSST AILASSSTTI FGFLALLFMS FQLGPDLGLV
LAKGVVFSLI CVIFFMPALM QVMDRAIAAT SHRSFLPSFA ALGRGISKIA VPLLAIAALL
PIAYVAQGMT DFRYGMGDYP TGSREAADRE FIQEEFGRAL PMALLVPRGQ WGTEHELEQE
LADLDAVTGI SSFQTQVGRL LPAEVLPQEQ LSSLLSENYS RIILTVDTAK EGAEAFAVVN
EVREIAGRHY PDAYHLTGES VVLEDMRASI TSDSVLVNLI AVGSVWLVLL ISFRSLLIPF
LLVLTIEGAI WINLSVPYLS GNYMVYIGFL VISTVQLGAT VDYAILFTQH YVSNRATRSK
HESIAHTVKE TFGTLLTPVL ILASAGLVLY LVSSLVVVSQ LGEVLARGAL ISFALVNLFL
PGMLIVFDRA IQKTTWKADF LRSKR
//
