ID A0A1M6E4I7_9FLAO Unreviewed; 785 AA.
AC A0A1M6E4I7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=SAMN05444337_0842 {ECO:0000313|EMBL:SHI80416.1};
OS Flavobacterium haoranii.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=683124 {ECO:0000313|EMBL:SHI80416.1, ECO:0000313|Proteomes:UP000184232};
RN [1] {ECO:0000313|EMBL:SHI80416.1, ECO:0000313|Proteomes:UP000184232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22807 {ECO:0000313|EMBL:SHI80416.1,
RC ECO:0000313|Proteomes:UP000184232};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; FQZH01000001; SHI80416.1; -; Genomic_DNA.
DR RefSeq; WP_072781999.1; NZ_FQZH01000001.1.
DR AlphaFoldDB; A0A1M6E4I7; -.
DR STRING; 683124.SAMN05444337_0842; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000184232; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000184232}.
FT DOMAIN 64..225
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 303..562
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 695..778
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 785 AA; 90479 MW; E6C7E6FBF42370C6 CRC64;
MFLNRFWQYI KRNKIKTTTG IILVVVYYFS LPKVLFKNDY ATVIESKEGQ LLGAKIADDG
QWRFPESDSI PHKFKTCIVA FEDQHFYKHF GFNPISMYHA FLQNRKANKV VRGGSTLTQQ
VIRLHRENQK RSYFEKFIEI ILATRLEFRC SKDEILGLYA AHAPFGSNVV GLEMASWRYF
GLQPHQLSWA EAATLAVLPN APSLIYPGKN QQRLLDKRNR LLKKLWQDKI IDKETYELAL
LENLPQKPFD VPQIAPHLLQ KTAKEHKGQK IKTTLSIYHQ ERVNDIVKQY YNLYKQNEVY
NIAVLVVDVK TRNIISYVGN SPTDKNHQKD VDIIEAPRST GSILKPFLYA SMLDDGDILP
ESLIPDIPTQ ISGYSPQNYN LTYDGAVPAN RALARSLNIP AVLMLQEYSV NKFYEQLQNL
KLRNVNRQPS NYGLSLILGG AETNLWDLCR AYSFMSGTVN HFTATQDEYR TNELANLNYN
WDEKVNFGKS VQNKNIWNVG AIWETFEAMK EVNRPEGDEA WQFYDSSIEI AWKTGTSFGG
RDAWAVGVNK DYVIGVWVGN ATGEGRPLLT GVESAAPILF DVFRIFPRSK WFETPYNDLE
EVSICKNSGF LATNTCPGEL KWVPKTAKKS KNCPYHKLIH LDQTKQYRVN SSCEAIENMV
TNSWFVLPPV MEWYYKKKNI DYKPLPPFKE NCENNDVSKK MDFIYPTSFT KIILTKNFEG
NTQPTIFKVA HSNQEEELFW YLNKKYLGST KTFHEMAIIA SSGIYTITVI DQEGTEIKRK
VEIEK
//
