ID A0A1M6E722_9BACT Unreviewed; 359 AA.
AC A0A1M6E722;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=SAMN05720471_10859 {ECO:0000313|EMBL:SHI81160.1};
OS Fibrobacter sp. UWP2.
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=1896216 {ECO:0000313|EMBL:SHI81160.1, ECO:0000313|Proteomes:UP000184414};
RN [1] {ECO:0000313|EMBL:SHI81160.1, ECO:0000313|Proteomes:UP000184414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWP2 {ECO:0000313|EMBL:SHI81160.1,
RC ECO:0000313|Proteomes:UP000184414};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FQYM01000008; SHI81160.1; -; Genomic_DNA.
DR RefSeq; WP_073189074.1; NZ_FQYM01000008.1.
DR AlphaFoldDB; A0A1M6E722; -.
DR STRING; 1896216.SAMN05720471_10859; -.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000184414; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF3; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 1..227
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 359 AA; 40159 MW; 5218ADBF7CC84572 CRC64;
MNLVLSLTEQ CNLRCTYCYY KESHAGRVKV MSDEVMEAAI GLAVRRTVAF RQRRLNITFF
GGEPLLRFDA IKRGVEYAKK VVSETAPQGF VVRFAVNTNG TLLNDEIVDF MKRENFQIFL
SLDGSAERHN ICRRQVNGEG SFDLIAPHIK TLVNTDVIVL AVITRDNIRG LCDSFRWLYA
QGFKNITSAV DFDGKWTEEE LDALGAEYQK LAELWVQKKK AGDVFYLGTI HDKVKIAVEG
SRYRLYSCHV YEGGLSVATD GSIFPCTRFI ASDPEAPYCQ GNVFTGVDEH RANAVHEFVH
NDKAACEGCA IRHRCTAHEC ACTSFYTTGT LEGVSPEVCA HERMLAAICD DAADMILTK
//
