ID A0A1M6EI15_9FLAO Unreviewed; 924 AA.
AC A0A1M6EI15;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN ORFNames=SAMN04488508_103416 {ECO:0000313|EMBL:SHI85071.1};
OS Aquimarina spongiae.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Aquimarina.
OX NCBI_TaxID=570521 {ECO:0000313|EMBL:SHI85071.1, ECO:0000313|Proteomes:UP000184432};
RN [1] {ECO:0000313|Proteomes:UP000184432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22623 {ECO:0000313|Proteomes:UP000184432};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; FQYP01000003; SHI85071.1; -; Genomic_DNA.
DR RefSeq; WP_073315746.1; NZ_FQYP01000003.1.
DR AlphaFoldDB; A0A1M6EI15; -.
DR STRING; 570521.SAMN04488508_103416; -.
DR OrthoDB; 9759785at2; -.
DR Proteomes; UP000184432; Unassembled WGS sequence.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR032106; 2-oxogl_dehyd_N.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000184432};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 582..775
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 924 AA; 105284 MW; 25EFF0D2B263F86E CRC64;
MDKYSFLNAA HTAFFAELYD QYLQSPDSVE PSWRAFFQGF DFGLENADGF GETIYVEKET
QGTIAVPENV QKEFQVVRLI DAYRTRGHLF TKTNPVRERR KYTPTLALEN FGLSQSDLNT
VFNAGEIIGI GPNTLSNIVV HLEKIYCDAI GIEYMYIRNP EEREWIQARV NFNTNRTKFS
ADQKKHILKK LNQAVSFENF LHTKYVGQKR FSLEGGESLI PALDALVEKA ADLGVKEFVM
GMAHRGRLST LTNIFGKSPK DIFSEFDGKD YEEAVFDGDV KYHLGWTSKR KTDSGKDINM
NIAPNPSHLE TVGAVVEGIT RAKQDRHYQE NTSAVLPIVV HGDAAVAGQG LVYEIVQMAK
LDGYKTGGTI HIVVNNQIGF TTNYLDARSS TYCTDVGKVT LSPVLHVNAD DAEAVVHAAN
FALDFRMTFK RDVFIDLLGY RKYGHNEGDE PRFTQPKLYK AIAKHRNPRD IYAEKLMAEG
IIDKDYVTKL EKEYKASLEE ELEDSRKQEK TVITPFMQDE WAGFERVQED EMMDVVKTAY
PKTKLTEIAE VITKLPSDKK FLRKIERLIE KRHKMFFETN ELDWAMGELL AYGSLLKEGY
DVRMSGQDVE RGTFSHRHGV IKVEDSEEEV TLLNTLKGDQ GDFYIYNSLL SEYGVLGFDY
GYAMASPDTL TIWEAQFGDF SNGAQIMIDQ YISSAEDKWK LQNGIVMLLP HGYEGQGAEH
SSARMERYLQ LCAKDNMFIA DVTTPANMFH LLRRQMKAKY RKPLVVFTPK SLLRDPKAVS
SVEEFTKGSF QTVIDDPDAT AKDVKSLVFC TGKFYYDLLE EKEKQGRNDV ALVRIEQLFP
LPAAEMDKVI KKYKADEVVW AQEEPRNMGA LSHMLMHYDG AKSFRFASRR PYGAPAAGSA
TRSKRRHQEV IDYVFDKTKD NQRR
//
