ID A0A1M6EWD0_9RHOB Unreviewed; 558 AA.
AC A0A1M6EWD0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000256|HAMAP-Rule:MF_01543};
DE EC=6.3.4.3 {ECO:0000256|HAMAP-Rule:MF_01543};
DE AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000256|HAMAP-Rule:MF_01543};
DE Short=FHS {ECO:0000256|HAMAP-Rule:MF_01543};
DE Short=FTHFS {ECO:0000256|HAMAP-Rule:MF_01543};
GN Name=fhs {ECO:0000256|HAMAP-Rule:MF_01543};
GN ORFNames=SAMN04488012_103242 {ECO:0000313|EMBL:SHI89679.1};
OS Palleronia salina.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Palleronia.
OX NCBI_TaxID=313368 {ECO:0000313|EMBL:SHI89679.1, ECO:0000313|Proteomes:UP000184040};
RN [1] {ECO:0000313|EMBL:SHI89679.1, ECO:0000313|Proteomes:UP000184040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26892 {ECO:0000313|EMBL:SHI89679.1,
RC ECO:0000313|Proteomes:UP000184040};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC EC=6.3.4.3; Evidence={ECO:0000256|HAMAP-Rule:MF_01543};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|HAMAP-Rule:MF_01543}.
CC -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC {ECO:0000256|HAMAP-Rule:MF_01543}.
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DR EMBL; FQZA01000003; SHI89679.1; -; Genomic_DNA.
DR RefSeq; WP_073127941.1; NZ_FQZA01000003.1.
DR AlphaFoldDB; A0A1M6EWD0; -.
DR STRING; 313368.SAMN04488012_103242; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000184040; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00477; FTHFS; 1.
DR Gene3D; 3.30.1510.10; Domain 2, N(10)-formyltetrahydrofolate synthetase; 1.
DR Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01543; FTHFS; 1.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01268; FTHFS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW Ligase {ECO:0000256|HAMAP-Rule:MF_01543, ECO:0000313|EMBL:SHI89679.1};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563, ECO:0000256|HAMAP-
KW Rule:MF_01543}; Reference proteome {ECO:0000313|Proteomes:UP000184040}.
FT BINDING 67..74
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01543"
SQ SEQUENCE 558 AA; 58689 MW; 5C46CB44DA19CD8F CRC64;
MAFTSDIEIA RAAKKRPIGE IGAKLGIGAD DLVPYGHDKA KIGQPFIDSL ADRPNGKLIL
VTAVNPTPAG EGKTTTTVGL GDGLSAIGKK AAICIREASL GPCFGMKGGA AGGGYAQVVP
MEDMNLHFTG DFHAITSAHN LLSAMIDNHI YWGNELGIDT RRVTWRRVMD MNDRALRQIT
TSLGGVANGF PREAGFDITV ASEVMACLCL ASSLADLQDR LGAIIVAYTR DRTPVYARDI
KADGAMTVLL KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATTTA LKLADYVVTE
AGFGADLGAE KFMNIKCRKA GLAPDCVVLV ATVRAMKMNG GVKKADLGAE NVDAVQAGCA
NLGRHLENLR GFGVPVVVAI NHFAGDTEAE IAAVQDFIAG QGAEAILCKH WANGSDGTRD
LAAKVVATIE AGGADFAPLY PDEMGLADKI DTICRRIYRA DGAQMDSKIR AQLKQWEDQG
HGHLPVCMAK TQYSFSTDPE ARGAPTGFTI PVREVRLSAG AGFVVAICGE IMTMPGLPRV
PSAEAIGLND AGDIEGLF
//