ID   A0A1M6FJY7_9FLAO        Unreviewed;       801 AA.
AC   A0A1M6FJY7;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SHI97939.1};
GN   ORFNames=SAMN04488513_102457 {ECO:0000313|EMBL:SHI97939.1};
OS   Pseudozobellia thermophila.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Pseudozobellia.
OX   NCBI_TaxID=192903 {ECO:0000313|EMBL:SHI97939.1, ECO:0000313|Proteomes:UP000184543};
RN   [1] {ECO:0000313|Proteomes:UP000184543}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19858 {ECO:0000313|Proteomes:UP000184543};
RA   Varghese N., Submissions S.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; FQYU01000002; SHI97939.1; -; Genomic_DNA.
DR   RefSeq; WP_072991217.1; NZ_FQYU01000002.1.
DR   AlphaFoldDB; A0A1M6FJY7; -.
DR   STRING; 192903.SAMN04488513_102457; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000184543; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184543}.
FT   DOMAIN          7..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..307
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   801 AA;  88913 MW;  FB8023B15EC7502D CRC64;
     MNKHISKVAV IGSGIMGSGI ACHFANIGVE VLLLDIVPRE LNDKEKKKGL SLDDKVVRNR
     LVNESLASAL KSKPSPIYHQ KFASRITTGN LEDDISKVSE VDWIIEVVVE RLDIKKQVFE
     NLEKHRTPGT LITSNTSGIP IKFMSEGRSE DFQKHFCGTH FFNPARYLKL FEIIPGPKTS
     PEVLEFLNGY GEKFLGKTSV VAKDTPAFIG NRIGIFSIQS LFHMVKELGM TVEEVDKLTG
     PVIGRPKSAT FRTVDVVGLD TLVHVANGIY ENCPDDERHE LFKLPDFIDT LMENKWLGSK
     TGQGFYKKSK DKDGKTEILT LDLDTMEYRS KKSAKFATLE LTKTIDKVID RFPVLTAGKD
     KAGEFYRKSF GQLFAYVSHR IPEISDELYK IDDAMKAGFG WEHGPFQIWD AVGLEKGLEF
     IKSENQEAAA WVEEMKASGV DSFYTVKDGA TYFYDISKKA MEKVPGQDAF IILDNIRKTK
     KVFKNKGVVV EDLGDGILNV EFQSKMNTIG GDVLAGLNKA LDMAEKDYQG LVVGNQAANF
     SVGANIGMIF MMAVEQEYDE LNMAIKMFQD TMMRMRYSSI PTISAPHGMT LGGGCELSLH
     ADKVVAAAET YIGLVEFGVG VIPGGGGSKE FAVRAQDTFK KNDVELNVLQ EYFLTIGMAK
     VSTSAYEAYD LGILQPGKDI VVVNKDRQIA TAKAHALLMA EAGYTKPIKR KDIKVLGKQA
     LGMFLVGTDS MEASHYISEH DKKIANKLAY VMAGGDLSEP ALVDEQYLLD LEREAFLSLC
     TERKTLERIQ HMLKTGKPLR N
//