ID   A0A1M6GJ60_9BACT        Unreviewed;      1262 AA.
AC   A0A1M6GJ60;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Cu(I)/Ag(I) efflux system membrane protein CusA/SilA {ECO:0000313|EMBL:SHJ09948.1};
GN   ORFNames=SAMN02745181_1184 {ECO:0000313|EMBL:SHJ09948.1};
OS   Rubritalea squalenifaciens DSM 18772.
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Rubritaleaceae; Rubritalea.
OX   NCBI_TaxID=1123071 {ECO:0000313|EMBL:SHJ09948.1, ECO:0000313|Proteomes:UP000184510};
RN   [1] {ECO:0000313|EMBL:SHJ09948.1, ECO:0000313|Proteomes:UP000184510}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18772 {ECO:0000313|EMBL:SHJ09948.1,
RC   ECO:0000313|Proteomes:UP000184510};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FQYR01000003; SHJ09948.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M6GJ60; -.
DR   STRING; 1123071.SAMN02745181_1184; -.
DR   InParanoid; A0A1M6GJ60; -.
DR   OrthoDB; 9757876at2; -.
DR   Proteomes; UP000184510; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 2.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 3.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR   Pfam; PF00873; ACR_tran; 3.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184510};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        411..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        508..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        548..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        591..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        621..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        654..675
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1074..1091
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1098..1119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1147..1170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1197..1216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1228..1252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1262 AA;  140104 MW;  80603794919EC518 CRC64;
     MSSLIQFCLR QKLVVILLLA FFVGWGIRVA PFDWETKIIP RDPVAVDAIP NLGDNQQIVF
     TPWSGRSPKD VDDQITYPMT VALMGVPGVK EVRSYSYFGF SSIYLVFEED IDFYWSRSRV
     LEKLNSLPSG TLPEGATPAL GPDATGLGQI FWYTLEGLDP DGNRVGGWDL DELRAIQDWQ
     VRYALQGTPG VAEVSSIGGY VREYQVDIDP DALRSQKITL VQVANAVRAS NKETGARNLS
     INGVEYIIRG VGYVKELDDI RKAVVASRNG TPITVGDVAS VSLGPAQRRG ALDKNGQEAV
     GGVVVARFGE NPLEVIQKTK ANIENLTSGL PQRAVILWDK TTPMEVREFF AELELPESAS
     EKEKTTQLTK YLQSHPRDQW PEWATLSKVT LVPFYDRTGL IGETLGTLND ALYQQILITI
     IVVVIMVLHL RSSILISAML PLAVLITFIA MKLFGVDANV VALAGIAIAI GTVVDIGIVL
     TENILKHLKE ADPDESRLEV IQRASTEVAS AVTTSVATTV TSFLPVFLLT GENGRLYRPL
     AFTKTFALSA SLIVAITIIP PVAHMLMRRW SKQKESEKRP SLIGKIMKSR STNLGISIAV
     AMVVGWLLAG DWAPLGLDRA HLSNFFFVFL IVGSLLFFFW LFQKVYVRVL RWCLGNKVLF
     LSVPMVLLML ALVIWKGFAP VVSWIPGGTA VAESTFGKDL QNHFPGLKNE NRPRLDEGSF
     LLMPTTSTHA DIGEAMDALR QLDEAVSKIP EVTLVVGKLG RAESALDPAP ISMFENVIQY
     APEFKQDEHG RPIKYRYDED TESYVYSDQG ELIPDESGRP FRQWRPHIKS PDDIWREIEK
     AAFVLGTTSA PKLMPIETRL VMLQTGMRAP MGLKIKGPDL DTIEKVGVEI ETLLKDSGVD
     GLNPATVIAD RIVGKPYLEV IPDREAAARY GLNVADIHDA LEMAVGGKPV TTTIEGRERF
     SVRVRYMREK RDNIEDLQQV LLTAQDGALI PLSQIARVHY VRGPQMIKSE DTFLTGYVTF
     DKMDDAAQLD VIERVKDYLE KMQEERRLIL PPGVSYRFAG SYEEKQEFDR NMRLILPVTL
     FVIFVILYLQ FRSVPTTLTL LTAIAVACSG GFLMLWLYAQ PGFLDINLFG ANLRDLFQVR
     EVALSTAVWV GFIALFGIAT DDGVVITTYL KQSIEKHSPS DKEGIRKAVV EAGARRVRPC
     LMTTATTLLA LLPVLTSTGR GSDIMLPMAI PVFGGMTIEL LTMFVVPTLY CWQKELRLKR
     QK
//