ID   A0A1M6GQA2_9CLOT        Unreviewed;       696 AA.
AC   A0A1M6GQA2;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN02745176_02479 {ECO:0000313|EMBL:SHJ12154.1};
OS   Lutispora thermophila DSM 19022.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Lutispora.
OX   NCBI_TaxID=1122184 {ECO:0000313|EMBL:SHJ12154.1, ECO:0000313|Proteomes:UP000184442};
RN   [1] {ECO:0000313|EMBL:SHJ12154.1, ECO:0000313|Proteomes:UP000184442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19022 {ECO:0000313|EMBL:SHJ12154.1,
RC   ECO:0000313|Proteomes:UP000184442};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; FQZS01000016; SHJ12154.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M6GQA2; -.
DR   STRING; 1122184.SAMN02745176_02479; -.
DR   Proteomes; UP000184442; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000184442}.
FT   DOMAIN          20..297
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          298..563
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         41..48
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   696 AA;  81676 MW;  2C9597AB17D86905 CRC64;
     MGGRIILPFF KVLHMKADLR KLNKEQLEAV KHYKGPCLVI AGPGTGKTTV ITHRVMHLIK
     EYRVKPNEIL VITFTKAAAR EMEERFCKLP YYQKDYKRVA FGTFHSIFYR ILRAYKGYRL
     ENLLDEKEKY YVIKSIIKTL GYDFYEDEQV IESIISEMSY MYNTLANIDD YEASSIDNAV
     FKSVFKEYEK YKYYNDKYDY DDMLVHCYKL LISNEEILNS IRAKYRYILI DEFQDINKVQ
     FEIMRLIAYP DNNIFVVGDD DQSIYSFRGA DAGIMIEFSR IYNTAVKITL RYNYRSCSAI
     INSAMSLISN NKNRYEKKFV TVKDMGINPL VVRVEDFEQE AKIICQKIID HVNQGGSYSE
     FAVIHRTNLQ SRAFIDAFTI ANIPYVSYDG LASVYNHWLL KDILAYLKAA IGIDRRNSLI
     RIINKPNRYI PRYVIEENIG KEGDFLDNIA IYSSLNDFQR KSIYELKDSL CRIRSMTTSK
     AIKYIRGYIG YEEYIRDYAF AKSIDVKLFD ELLDEINSSS ESFAKINDYI EHVRIILESV
     DYKYNENRNT NAVSLMTMHK AKGLEFEQVF ISGAVDGVVP YIKGDDISLS ELEDERRLFY
     VAMTRAKRVL YIFVPKNRFS KKVYPSRFIR EIDSWLKDYR NSFKCGDKIN HKHFGDGIIK
     GIEKRAEDYI LTVEFKNDTK RLNLDVLLKN KIITLI
//