ID A0A1M6H6M8_9FLAO Unreviewed; 1439 AA.
AC A0A1M6H6M8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SHJ17832.1};
GN ORFNames=SAMN05444363_2888 {ECO:0000313|EMBL:SHJ17832.1};
OS Flavobacterium terrae.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=415425 {ECO:0000313|EMBL:SHJ17832.1, ECO:0000313|Proteomes:UP000184488};
RN [1] {ECO:0000313|Proteomes:UP000184488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18829 {ECO:0000313|Proteomes:UP000184488};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; FQZI01000007; SHJ17832.1; -; Genomic_DNA.
DR RefSeq; WP_023571593.1; NZ_FQZI01000007.1.
DR STRING; 415425.SAMN05444363_2888; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000184488; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184488};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 344..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1042..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 1130..1160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1339..1370
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1439 AA; 159731 MW; A162624E46236EB1 CRC64;
MLDKIIQFSI KNKFIILLLT LVLIAWGSYS IKQLPLDALP DVTNNQVQII TTAPTLASQE
VEQLITYPLE QSVKTIPKVI ELRSISRFGL SVVTVVFKDD VDIYWAREQI FQRLKQAEEN
IPDYAGSPEL APISTGLGEI YQYDVYAKKG YEDKYDAIKL RTIQDWIIIP QLQGIEGVAE
VSTWGGKLKQ YEVAVNPNTL NSLGVTITEI FDALEKNNQN TGGAYIEKDQ YAYFIRGVGM
ATGIKDLENV VVKNRNGAPV LVRDVATVRE GIALRYGAST KDGKGEIVCG LALMLKGENS
SAVVERVKEK MVQINKTLPE GVVAEAFIDR GKLVDNAIGT VTKNLLEGAL IVIFVLILFL
GNLRAGLIVA SVIPLSMLFA VILMNYFGVS GNLMSLGAID FGIIVDGAVI IVEATMHHLQ
KLKRQKDLTQ SEMDSEVYKS ASKIRNSAAF GEIIILIVYL PILALVGTEG KMFKPMAMTV
GFAVIGAFIL SLTYVPMMSA MFLSKNTEHK SNFSDRMMAW FEKIYTPFLE KALQIKKSVL
VIALGLFALA VITFQNMGGE FIPTIEEGDL AINATIMTGS SLTQMVETTT KYEKILKAKF
PEIKTIVTKI GSGEIPTDPM PIESGDLIIV LKDKSEWTSA DNWEDLANLM KEEMEAIPGA
NIEISQPIQM RFNELMTGSR SDIAIKIFGD DLEVLDTKAK ELISKINKIE GIGDLKADKV
TGLPQITVKY DYNKIALYGL NITDVNKIIR SSFAGESAGK IYEESKRFDV VVRMDAANRS
DITDVSNLFI PLPNGQQVPL SQVAAISYEQ GPVQVSRENG KRRITVGLNV RGRDIKSVVE
EIQQKLETNF KLPAGYYITY GGQFENLVEA NKRLSIALPI ALGLIMVLLF FTFNSVKQSL
LIFTAIPLSA IGGVFALWLR GMPFSISAGI GFIALFGIAV LNGIVLISYF NQLKSEGITD
PLQRVLMGTK TRLRPVLMTA AVASLGFMPM ALSTSGGAEV QKPLATVVIG GLFSATLLTL
IVLPILYLLF ENGMKIRKFK KRQPFVTLWF LLISCVALSQ NKQTVTLDQA ITLAKKSNID
LKIADKEIEK QTTLKKAAFQ VDPLQVQYQG GQFNSVDYDH NVSVQQYFPI GKITKANRQL
QEELAKLAEK RKALSEYEIE KAVTLAYYQY LYGVSIQKLN NELSDIYIKF LKNAELRFQT
GESGNIEVIS AKAKVKEIET QKLQLEYDLA VYQKQLQYFI QTDENIVPDA ATPLKYEKNV
SIAEDKVQGL VNDYYTQQIS VYQKEANIFK AMRTPKLGLG YFGQTIDTKS YFQGFTAGLQ
IPLFGGVNSA RAKASEISVV QAQLELDKSK LALKLQKEEL KSEFDKQNKA MLYYQNEGLQ
YADQIITTAQ KSYANGDMSY WSYISFLNQA IDIKKQNAEA VNAYNQSAIQ LQFPSFSNN
//
