ID   A0A1M6HEW8_9CLOT        Unreviewed;       697 AA.
AC   A0A1M6HEW8;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE            EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE   AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE   AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE   AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE   AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN   ORFNames=SAMN02745975_01526 {ECO:0000313|EMBL:SHJ20673.1};
OS   Geosporobacter subterraneus DSM 17957.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Geosporobacter.
OX   NCBI_TaxID=1121919 {ECO:0000313|EMBL:SHJ20673.1, ECO:0000313|Proteomes:UP000184536};
RN   [1] {ECO:0000313|EMBL:SHJ20673.1, ECO:0000313|Proteomes:UP000184536}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17957 {ECO:0000313|EMBL:SHJ20673.1,
RC   ECO:0000313|Proteomes:UP000184536};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC         passage and rejoining.; EC=5.6.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000213};
CC   -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC       {ECO:0000256|ARBA:ARBA00009446}.
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DR   EMBL; FQZV01000017; SHJ20673.1; -; Genomic_DNA.
DR   RefSeq; WP_028309380.1; NZ_FQZV01000017.1.
DR   AlphaFoldDB; A0A1M6HEW8; -.
DR   STRING; 1121919.SAMN02745975_01526; -.
DR   OrthoDB; 9803554at2; -.
DR   Proteomes; UP000184536; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00186; TOP1Ac; 1.
DR   CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR   Gene3D; 3.40.50.140; -; 1.
DR   Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR   Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR   Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR003601; Topo_IA_2.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR013826; Topo_IA_cen_sub3.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR   InterPro; IPR005738; TopoIII.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR034144; TOPRIM_TopoIII.
DR   NCBIfam; TIGR01056; topB; 1.
DR   PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR   PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   PRINTS; PR00417; PRTPISMRASEI.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SMART; SM00436; TOP1Bc; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SHJ20673.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          1..134
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
SQ   SEQUENCE   697 AA;  77218 MW;  FE0BD5406ECD0DE8 CRC64;
     MKLIIAEKSS VGQAIASVLG ATERGDGYLE GGGYLVSWCA GHLVELAQAE TYDEKYGKWR
     YEDLPILPEH WKYAVSREKA KQLKVLRELM KRPDVDCIVN ACDAGREGEL IFRLVYEYCG
     CKKPIQRLWI SSMEESAITG GFRNLRPGTD YDRLYRAALC RLQADWLVGI NATRLFSVLY
     RQTLNVGRVM TPTLALLVQR EQEIAAFVRE PFYTPELNCG TFIVLGEKYK DRKAAESIHS
     ACNVKTAVVK SVERQEKTVV PPRLYDLTTL QREANRLFGF TAQQTLDYMQ SLYEKKLATY
     PRTDSRYLTE DMAAGLPALV ETAAAVLPFM KGIVPNVDAR RVVDNSKVTD HHAILPTGQI
     KDSDLAALPA GERNILFLLA VRLVCAVGEP HLYAETVVTV DCEGHSFTAK GKTVLQDGWK
     AIESAYRATL KNKPDKDGED KALPELSKGQ VFENVRTAVK EGFTSPPKSY SEDTLLKAME
     TAGSEDMPED AERKGLGTPA TRASIIEKLV KTGLAERKNK QLLPAKKGVS LIAVLPEIIK
     SPALTAKWEH RLKQVERGGL SDAEFMAGIA ELTVSLVKSN SALNPDFMRL FPAPVGSRSE
     AVGICPRCGG KVLEGKKGFL CENRDCGFAL WRDNRFFASK KKDLTRAIAA ALLEKGLVSL
     SGLYSEKTGK TYNAVVIMED TGKYVNFKLE FEKGAKK
//