ID A0A1M6HFR4_9BACT Unreviewed; 719 AA.
AC A0A1M6HFR4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05720471_12115 {ECO:0000313|EMBL:SHJ21026.1};
OS Fibrobacter sp. UWP2.
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=1896216 {ECO:0000313|EMBL:SHJ21026.1, ECO:0000313|Proteomes:UP000184414};
RN [1] {ECO:0000313|EMBL:SHJ21026.1, ECO:0000313|Proteomes:UP000184414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWP2 {ECO:0000313|EMBL:SHJ21026.1,
RC ECO:0000313|Proteomes:UP000184414};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FQYM01000021; SHJ21026.1; -; Genomic_DNA.
DR RefSeq; WP_073190724.1; NZ_FQYM01000021.1.
DR AlphaFoldDB; A0A1M6HFR4; -.
DR STRING; 1896216.SAMN05720471_12115; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000184414; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd07989; LPLAT_AGPAT-like; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00563; PlsC; 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:SHJ21026.1};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Transferase {ECO:0000313|EMBL:SHJ21026.1}.
FT DOMAIN 8..271
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 719 AA; 82504 MW; 1B8441EE188AC619 CRC64;
MDAQSILDGL NSDQRAAVLH DHQKGAQLLI LAGAGSGKTS VLTKRIQYRI AMGVDPEKIL
ALTFTAKAAA EMRERVQKLF PKAGVRLCTF HSLALFMLKQ KIGSRFAYEM VGFKKPPVPQ
ESAERDFLTK LSRLRIPSGK LNREELFADT YPASLVPKLK TLRQGVLDSG SVVFEDLIYL
AISLLEKHRE ARDYFRAQWS EILVDEYQDI NPSQYRLVKA LLGSRKELFV VGDDDQAIYG
FRGADIGNIN RFCEDFKESS LIRLEWNYRS VPEILHLANS IFENKPLRLR KVLRAGNTRG
SGGNPLYREN RRPEVWYSEN PVEEMLKIVG WIKELRESYE LEWKNFAILV RYNRQRLYYE
AALKDAGLPI AGVELDEGET LENGVHVETV HASKGLQYAV VFYAGLAEGL TPGECQGSRA
ERQRQLDEER RLYYVGVTRA EAYLILLYCK QRFWKGKLRK FKKSRFLPQA RPKNEELKLP
LILFKIYVVV RVLFVMFEHI LKLPFVYLFH KNEVDLWVDK KIQWFSNFCM DIINIDLTIE
DQALLGKVDW TRPVFVMGNH NSFVDIPVVF LTIERTIGFI AKAQLGRIPF LNFWMHKIGC
IFINREKGGG ADLVREALAH GRVPRISVFP EGTRGKSDDL APFKSGSFRL AIEAQATILP
VVIKGSAGAW ERRRDCGRKK VTSRVLEPID VRALMQEKGE LEPRRDLMNV IRERMETAL
//
