ID A0A1M6HMW0_9CLOT Unreviewed; 1226 AA.
AC A0A1M6HMW0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05444401_2580 {ECO:0000313|EMBL:SHJ23508.1};
OS Clostridium amylolyticum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121298 {ECO:0000313|EMBL:SHJ23508.1, ECO:0000313|Proteomes:UP000184080};
RN [1] {ECO:0000313|EMBL:SHJ23508.1, ECO:0000313|Proteomes:UP000184080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21864 {ECO:0000313|EMBL:SHJ23508.1,
RC ECO:0000313|Proteomes:UP000184080};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FQZO01000003; SHJ23508.1; -; Genomic_DNA.
DR RefSeq; WP_073007114.1; NZ_FQZO01000003.1.
DR AlphaFoldDB; A0A1M6HMW0; -.
DR STRING; 1121298.SAMN05444401_2580; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000184080; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF1; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SHJ23508.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000184080};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 314..532
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
SQ SEQUENCE 1226 AA; 144110 MW; C6B2F59A2129C7BB CRC64;
MDKNKIKSFA VWARRKLISS VQDRARYIGI FIDNEGKYNE LKAEQVQGGF KLEGVEGVFK
LSYKDRKVLT NRIRSYEDNK KGFEQVMEEV AYTWFNRFMG LRYMEVNDYL PTSIRILSSE
IEGKTEPDVL TRVSEVIDEL ELNADYIYEL LDSGKTEDRE EAYKHILVKQ CNELGKIIPQ
MFEKISDYTE LLLPDNLLEE GSVIRRMVDD IEESDWREEV EIIGWMYQYY ISEKKDEVFA
ALKKNVKITK ENIPAATQLF TPKWIVKYMV ENSLGRLWLE GHPNEELQKQ WRYYLEEAEQ
DPEVEEELKK IREENSKLKP EDIKVLDPCM GSGHILVYAF DVLYEIYKSA GYSEREIPRL
ILQNNLYGLD IDDRAAQLAS FALIMKARHY NRRLFREIEK ENIDLNLCSI QESNDITKEV
MDYFVQGNEE LRKDTEYLVA VFTDAKEYGS ILEVEQVNFQ ALKQRLKEIE EDQNFMFGDY
RRIILDKLPI IIKQAEIMSR KYEICVTNPP YMGNRGIGKK LNKYLKDNYS KSKSDLSTVF
MEKCISKCKN KGYMSMINIP TWMFIKTYNK FRENLLDENG IVNLTHLGRG VFGSDFGSTA
FIIRKGFKDN YKGLYKKLFD NQVDVDSLEN KEKLFLEGYQ TFITKQQIFD VIPTRPIAYW
ISNRVVDIYN NSANVGTYSE VTNGLFTCNN DYFLKMWYEV NLNKCIFNCE NMNETEEINK
KWLPYNKGGA FRKWYGNHEN IINYKDSGRE VREFRVKQGQ SSSFPGEKYY LNESLSWSFV
SYSTFGVRFY PKGFVFDIAG SSVFADRETL LYLAGYLCSK VAYEFLKINP TINYQAGNID
SLPIIFVEDK KERIKILVNN SIEISKLEWN SFETSWNFKI HPLLNFLDKV KDFKLSSSFE
VWKNECDVNF NKLKANEEEL NRIFIDIYGL QNELTPEVED KDITIRKADR ERDIKSFISY
AIGCMLGRYS IDVEGLVYAG GDFEDKWSFG DKKVRKIVKD DNGNVVEDSW VDATFLPDED
NIIPITEDEY FEDDIVTRFI EFVRTVYGEV TLEENLDFIA DSIGRKSSET SRQAIRRYFV
KDFYKDHLKV YQKRPIYWMF DSGKNDGFKA LIYMHRYDGQ TVARVRTDYL HKLQRKYEAE
IQRQQLIVDS DKSTVKDKTT AKKNIDRIAK QIEECREYDQ VVAHIANERK PIDLDDGVKV
NYSKFQEVKV INSKGKEVKM DLLAKI
//