ID A0A1M6HYX0_9BACE Unreviewed; 668 AA.
AC A0A1M6HYX0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Twinkle protein {ECO:0000313|EMBL:SHJ27365.1};
GN ORFNames=SAMN05444350_12067 {ECO:0000313|EMBL:SHJ27365.1};
OS Bacteroides stercorirosoris.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=871324 {ECO:0000313|EMBL:SHJ27365.1, ECO:0000313|Proteomes:UP000184192};
RN [1] {ECO:0000313|EMBL:SHJ27365.1, ECO:0000313|Proteomes:UP000184192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26884 {ECO:0000313|EMBL:SHJ27365.1,
RC ECO:0000313|Proteomes:UP000184192};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FQZN01000020; SHJ27365.1; -; Genomic_DNA.
DR RefSeq; WP_025831523.1; NZ_FQZN01000020.1.
DR AlphaFoldDB; A0A1M6HYX0; -.
DR eggNOG; COG0305; Bacteria.
DR Proteomes; UP000184192; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR CDD; cd01029; TOPRIM_primases; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR027032; Twinkle-like.
DR PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR Pfam; PF01751; Toprim; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56731; DNA primase core; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 382..645
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT REGION 85..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 75446 MW; 2D82F0A779B19F39 CRC64;
MKPFYYLCDF PERKNAGKNF VTECPKCGKK HLYISKTTGV FHCFSSGCDF KGKLKDFWEE
RPSYNSSFTG TAGDKFMGTH YPTHNIRQER ESGNGSGKAT SEVPMIPEDY KKLPPEVFSK
IKPLTDDPET KDQNQLAARR YLADQGISLK TAIEARIGCL MHRCYGKDED NKSTGTMYHC
IAYVNFLNGQ PVNVKYRSCD PSTIKATDEG ETTGREKAAG YTKFWSQDSP TTPCPPYHID
CINPLKVAEE TVPRLIITEG EKDVLTLREA GYHYVISVPN GAASDLSKSF EAFEPWMNQA
RDIVICGDID LPGRTLVKHL TDYFGERCLL TTLPGDCKDI SDVLATYGIE VVHEIIESAR
PQHTADIVTV SERANGILNV LHGEYDHGYD VGYGPLTDHV FHPTDQGGLI IETGVPNSGK
TDFLNDLTCR LMAKTGRYVC YLSFEVPDKD KHIAHLVQLM LGKVNTANYT QEQLKPIISF
LDSHMVHLDL HEVSPTPNNI IARADMVRRT LPLKYLIIDP YLFMEVETNR YNTETQAIKA
MLTQMQAWGR TNNIWVIIVA HPRKLTKLNG KNELEEIDMY TIAGSANWAN LADFIFSISR
INRQDSNYTR LDMLKVRDQD LCQTGSVLYV RQTCGRYDER ESEEQVIAEA QGKVMSKDHS
PWISLIES
//
