ID A0A1M6IZ67_PSEXY Unreviewed; 710 AA.
AC A0A1M6IZ67;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN02745725_02454 {ECO:0000313|EMBL:SHJ39755.1};
OS Pseudobutyrivibrio xylanivorans DSM 14809.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Pseudobutyrivibrio.
OX NCBI_TaxID=1123012 {ECO:0000313|EMBL:SHJ39755.1, ECO:0000313|Proteomes:UP000184185};
RN [1] {ECO:0000313|EMBL:SHJ39755.1, ECO:0000313|Proteomes:UP000184185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14809 {ECO:0000313|EMBL:SHJ39755.1,
RC ECO:0000313|Proteomes:UP000184185};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FQYQ01000020; SHJ39755.1; -; Genomic_DNA.
DR RefSeq; WP_072918474.1; NZ_FQYQ01000020.1.
DR AlphaFoldDB; A0A1M6IZ67; -.
DR STRING; 185007.SAMN02910350_00175; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000184185; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000184185}.
FT DOMAIN 12..292
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 293..544
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 710 AA; 81794 MW; 22D6F81A150B67EB CRC64;
MLEKQFIELY TSQLNEQQME AVRTVEGPVL LLAVPGSGKT TVLVNRLGYM IYCKGIAPEN
ILTLTYTVAA TKDMANRFEK IFGPDLSDRL EFRTINGICS KVIAYYGRMI GKNSFELLTD
EKEIIRLLSS IYLNVEGEYP TESDIKNIRT LITYCKNMYL TGDEIDKLGK DEDINLRKIY
EAYNNELKNH SLMDYDDQML YAYRILKGSP VVLNYYRKMY KYICVDEAQD TSKIQHMIIS
LLSGESGNLF MVGDEDQSIY GFRAAYPDAL LNFERNHVGA KVLVMDKNYR SNAKIVEAAD
IFIQHNKDRH KKHICATKDA KSEISFVKID REKQYSYLVK VAENVNTKTA VLYRDNESVL
PLVDALERQS VSYNIKNVDM AFFTNRVVID IINMLQFAFV PMDAELFMKI YFKFQLYLSK
KDAIEMCELA ERNHSDVLDA IELLNLKGHV LGNCKSLRTH YRNMVDETPY KAINRIENFM
GYGDYLNDNN IDTNKIFILK MLAKKEKDIP SFLNRLNELR RILMEKKNDS SSKLILSTIH
SSKGLEYDSV ILMDVINGVF PNKVLRANTK ATPQEKRDYE EERRIFYVGM TRAKDKLTIF
KYENRNSTFI NELKPETKNA EIENKASYSA TKVTSYFKQP KVTSKGNESA PDRLIIGQVV
SQKKYGKGAI TDVILSDDGQ PEKFSVQFES GVEKDFMFPN AFSYGMKIMD
//
