ID A0A1M6JPQ1_9CLOT Unreviewed; 512 AA.
AC A0A1M6JPQ1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Citrate lyase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE Short=Citrase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE EC=2.8.3.10 {ECO:0000256|PIRNR:PIRNR009451};
DE EC=4.1.3.6 {ECO:0000256|PIRNR:PIRNR009451};
DE AltName: Full=Citrate (pro-3S)-lyase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE AltName: Full=Citrate CoA-transferase subunit {ECO:0000256|PIRNR:PIRNR009451};
GN ORFNames=SAMN05444401_3181 {ECO:0000313|EMBL:SHJ48606.1};
OS Clostridium amylolyticum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121298 {ECO:0000313|EMBL:SHJ48606.1, ECO:0000313|Proteomes:UP000184080};
RN [1] {ECO:0000313|EMBL:SHJ48606.1, ECO:0000313|Proteomes:UP000184080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21864 {ECO:0000313|EMBL:SHJ48606.1,
RC ECO:0000313|Proteomes:UP000184080};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + citrate = (3S)-citryl-CoA + acetate;
CC Xref=Rhea:RHEA:19405, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57321; EC=2.8.3.10;
CC Evidence={ECO:0000256|PIRNR:PIRNR009451};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = acetate + oxaloacetate; Xref=Rhea:RHEA:10760,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089; EC=4.1.3.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR009451};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR009451}.
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DR EMBL; FQZO01000005; SHJ48606.1; -; Genomic_DNA.
DR RefSeq; WP_073008827.1; NZ_FQZO01000005.1.
DR AlphaFoldDB; A0A1M6JPQ1; -.
DR STRING; 1121298.SAMN05444401_3181; -.
DR OrthoDB; 9767643at2; -.
DR Proteomes; UP000184080; Unassembled WGS sequence.
DR GO; GO:0009346; C:ATP-independent citrate lyase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008815; F:citrate (pro-3S)-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008814; F:citrate CoA-transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 2.
DR InterPro; IPR006472; Citrate_lyase_asu.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01584; citF; 1.
DR PANTHER; PTHR40596; CITRATE LYASE ALPHA CHAIN; 1.
DR PANTHER; PTHR40596:SF1; CITRATE LYASE ALPHA CHAIN; 1.
DR Pfam; PF04223; CitF; 1.
DR PIRSF; PIRSF009451; Citrt_lyas_alpha; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR009451};
KW Lyase {ECO:0000256|PIRNR:PIRNR009451, ECO:0000313|EMBL:SHJ48606.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000184080};
KW Transferase {ECO:0000256|PIRNR:PIRNR009451, ECO:0000313|EMBL:SHJ48606.1}.
SQ SEQUENCE 512 AA; 54597 MW; 2B6F61247BC3CAF4 CRC64;
MKNLVGIELP EYIEGYGKVE PYSGAFNEKL VKSRREIPSK MVKPEDSKVL ASIDEAFEKV
GLKDGMTLSF HHHLRNGDYV LNMVLERAAA KGIKNLTIAA SSIFPIHAPL VEHIKNGVVT
KIIASYISGP VAHAVSKGML KNPVVMQTHG GRARSIESGE VKIDVAFVAA PTADTYGNIN
GVQGKSACGA LGYAVADCMY GDHVVAITDN LVPYPACPIE ISQIYVDYVV QVESIGNPAG
IVSGTTKITK DPIGLKIARD AAKVIKNSGL FKDGMSFQTG AGGTSLAVAK EVKEMMIKDK
IKGSFASGGI TGYLVDMLKE GLFEGIMDVQ CFDIEAVESY ASNPKHQGMS ASMYGNPHNK
GAVVNNLDVV ILGATEIDTS FNVNVTTGSD GIIMGGSGGH SDTAAGAKLT IIVSNLMKAR
LPIIKDKITT ITTPGETVDV LVTERGVAVN PKRQDIMEKL QGTGLKLYSI EELKDIAEKF
TGKPKEIPLE EDIVAVVEYR DGSVIDLIKK VK
//
