ID   A0A1M6LR70_9FIRM        Unreviewed;       938 AA.
AC   A0A1M6LR70;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=NlpC/P60 family protein {ECO:0000313|EMBL:SHJ73693.1};
GN   ORFNames=SAMN02745243_01263 {ECO:0000313|EMBL:SHJ73693.1};
OS   Hespellia stercorisuis DSM 15480.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Hespellia.
OX   NCBI_TaxID=1121950 {ECO:0000313|EMBL:SHJ73693.1, ECO:0000313|Proteomes:UP000184301};
RN   [1] {ECO:0000313|EMBL:SHJ73693.1, ECO:0000313|Proteomes:UP000184301}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15480 {ECO:0000313|EMBL:SHJ73693.1,
RC   ECO:0000313|Proteomes:UP000184301};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C40 family.
CC       {ECO:0000256|ARBA:ARBA00007074}.
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DR   EMBL; FQZY01000015; SHJ73693.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M6LR70; -.
DR   STRING; 1121950.SAMN02745243_01263; -.
DR   Proteomes; UP000184301; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd14667; 3D_containing_proteins; 1.
DR   CDD; cd12797; M23_peptidase; 1.
DR   Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR   Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR   InterPro; IPR011055; Dup_hybrid_motif.
DR   InterPro; IPR000064; NLP_P60_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR016047; Peptidase_M23.
DR   PANTHER; PTHR21666:SF270; OUTER MEMBRANE ANTIGENIC LIPOPROTEIN B; 1.
DR   PANTHER; PTHR21666; PEPTIDASE-RELATED; 1.
DR   Pfam; PF00877; NLPC_P60; 1.
DR   Pfam; PF01551; Peptidase_M23; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR   PROSITE; PS51935; NLPC_P60; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184301};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        381..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          815..938
FT                   /note="NlpC/P60"
FT                   /evidence="ECO:0000259|PROSITE:PS51935"
FT   REGION          1..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          293..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..146
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..329
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   938 AA;  104674 MW;  7DFD4EACFA1C8B95 CRC64;
     MAEQRMKVRD KKVQKMTKDG LVEENLTDKS SVRVSNRVGD VQMGRKQGEK EENLVDKSPR
     QSERSGKNIR PSVQKSRDAP ELIRTEKQSE DFGQSSKQQN RKRIRAEVGK ESRLAEESEA
     GQSGRLKEKR ADLSENRGDS RRNQTGGSKK PKQKQRLKFA YEETGASVKN DKDMEKLNQM
     DTDGVNFRHQ KQKEKAKKFS YEEARKKKEA KQHSKKAQVY QANEGETPGK KKSRLKFGEG
     ESVKTEKTSV VKKAGSATSV ALHREISKNE DDNAAVEGAH KLEESGEGVY RLEQRSARRR
     KQWASRKRSR LERQEEKQAQ AASHQEQKKL KKQIQKQQIK WDYAKAKRSE QTVGTATKGT
     IDYIKKIGGK VTNFFKENRK VYISVAVLIG LMFLIITNVT SCSAVFLQNV ITYTGTSYLS
     SDQAIREVEL YYTQLEANLQ ERINNMESEE PGHEEYRYNI GPIEHDPFIL ISYLSAKYEE
     FTFEQVKPEL DALFALQYRL ETEAVNETVT ETATVRVGES LGQVVTSGYC NCPICCGIWS
     GGPTASGAYP TANHTLAVDA SNPFVPMGTK VVMNGVEYTV EDTGAFARYG VQFDVYYDSH
     AAASAHGHQT WECYLADDNG SNEVEVTRTR DVDVLNVTLN SGNLMSICQD RLGFFQKELF
     SAYNDTKGNL QMFATPVDFN WYSSVTSYYG YRIHPISGAN QLHNGMDIGA PEGTKVMAGL
     TGTVTTSAYN DSYGNYVVIK DSKGYELRYA HLSSRSVSAG ASVTKGDEIG LVGNTGNSTG
     SHLHIELLKN GERLNPIFYL ETGEGAGFGG NEYTSEAAQR LLNEAARYLG TPYVWGGYSP
     SGFDCSGFVS YCLTHSGVRN TGRLTAQGLY DICTPVSQSE AQPGDLIFFT GTYDAGVPVT
     HIGIYVGNGQ MIHCGHPVQY TSINSPYWQS HFYGFGRW
//