ID   A0A1M6LU08_9CLOT        Unreviewed;      1037 AA.
AC   A0A1M6LU08;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN02745248_00818 {ECO:0000313|EMBL:SHJ74595.1};
OS   Hathewaya proteolytica DSM 3090.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Hathewaya.
OX   NCBI_TaxID=1121331 {ECO:0000313|EMBL:SHJ74595.1, ECO:0000313|Proteomes:UP000183952};
RN   [1] {ECO:0000313|EMBL:SHJ74595.1, ECO:0000313|Proteomes:UP000183952}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 3090 {ECO:0000313|EMBL:SHJ74595.1,
RC   ECO:0000313|Proteomes:UP000183952};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; FRAD01000006; SHJ74595.1; -; Genomic_DNA.
DR   RefSeq; WP_072902627.1; NZ_FRAD01000006.1.
DR   AlphaFoldDB; A0A1M6LU08; -.
DR   STRING; 1121331.SAMN02745248_00818; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000183952; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR011528; NERD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF08378; NERD; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000183952}.
FT   DOMAIN          321..645
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         342..349
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1037 AA;  120174 MW;  9F4DE109DC26D030 CRC64;
     MAMMMDIKDE TYKGEQKVYE CIESNLPDEI VCYYNREING KQFDFCLMME HMGVLVIEVK
     GWHLSNIIKV HNPDCIETTL YDEPVSSPKK QARSYKFALL NTFNNKYNVN PLIMDMVCYP
     FLSEADYKQC GLKVVSELEF TLFRDDIENP TKFAMKIAGV YQKTNQPVYD KLVGEVYKTC
     RLHFESSIEQ QEDANIDPYS ELRVYGSDIG ITDIDEIIKA YFKGVKQTVF LCNKEGVQQI
     AQNIYSKFNS DGIYLKGRNF IINSNQENKI KNFEEYIGFF NFEVFYIENL KDCVDGNIVI
     ENGKFSDDEI KIVSLIADKS KFNLQQYLVE HAPIEKNIVV KAGAGTGKTY SMISRISYIC
     HQSSGANILD VKNEIAMLTF TTEAATNMKS RLKQAFMNYF VLTREKKYLE MISGIENMRI
     STIHSFSNLV IKDTSLPLGI GVDFATVSGN FQKQKIFDKY FNEYLKKKND EEAMFFGTIP
     GSMYEFRKLL LRFSDMLYNK GYDIKDATED VFGSPVSEIP YMKEIIQDVI IATEKEYSEY
     LYENNSVSLV EYMLYLNKCV NDDSFNKNLY QYKFIFIDEF QDVDDSQIVA FLEMQKKLEF
     KFFIVGDLKQ CIYRFRGATM DAFKKMGCDS DEWRDYTLNI NYRTDRRLLD KFAVLFNSLG
     DKKLIPYVEP GDRLVGVNEN TSMGNCDLIE VYQYTKDDEK EDVVYKKLFE IIKERKSVIE
     SSESFDKLSN AEKTIAVLVR TNYQIASILR KARNQEDIVI ESDSNGDLYK LQSSIDLCKL
     TSALSNPRNP VYLFDLLLSN NVNIKFPVEK LVKLNEQEKM DYLVNCLDQF YLNTLGLTWA
     QLVFEIQSKP VLMVMRKIYD ATKPWKKYSL DEAKQAHYRS NYDLVFEDLS KEGKYSYLTL
     DSINESLHIL INMGSEKTSR SVSDGGDYVK IICTTVHKSK GLEYDTVIMP ITTDSIDTMH
     RNGLDVTYVE GKVGYCISVD GESMANEYFY TEDELDEIEM EEARILYVAL TRAINKFCWF
     DKTDSKGNTW GKLLEEM
//