ID   A0A1M6LWC6_9FLAO        Unreviewed;       796 AA.
AC   A0A1M6LWC6;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SHJ75451.1};
GN   ORFNames=SAMN05444337_2545 {ECO:0000313|EMBL:SHJ75451.1};
OS   Flavobacterium haoranii.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=683124 {ECO:0000313|EMBL:SHJ75451.1, ECO:0000313|Proteomes:UP000184232};
RN   [1] {ECO:0000313|EMBL:SHJ75451.1, ECO:0000313|Proteomes:UP000184232}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22807 {ECO:0000313|EMBL:SHJ75451.1,
RC   ECO:0000313|Proteomes:UP000184232};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; FQZH01000006; SHJ75451.1; -; Genomic_DNA.
DR   RefSeq; WP_072785699.1; NZ_FQZH01000006.1.
DR   AlphaFoldDB; A0A1M6LWC6; -.
DR   STRING; 683124.SAMN05444337_2545; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000184232; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184232}.
FT   DOMAIN          7..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..307
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   796 AA;  87891 MW;  52FB91EE970257CC CRC64;
     MKRNIKKVAV IGSGIMGSGI ACHFANIGVE VLLLDIAPRE LTEAEQKKGL TLESKAVRNR
     IVNEHLANAL KSKPSPIYHQ SFASRITTGN TTDDMAKIAD VDWIIEVVVE RLDIKKTVFE
     QVEKYRKPGT LITSNTSGIP IQFMSEGRSE DFQQHFCGTH FFNPARYLKL FEIIPGPKTS
     QEVLDFLNGY GEKFLGKTSV VAKDTPAFIG NRIGIFGIMS LFHQVKEMGL TIEEVDKLTG
     PVIGRPKSAT FRTVDVVGLD TLVHVANGIY DNCPNDEAHE LFKLPGFINT MMENKWLGSK
     TGQGFYKKEG KDILSLDLDT LEYRANKKAS FATLELTKTI DKPINRFKVL VGGKDKAGEF
     YRKNFSAMFA YCSNRIPEIT DAFYKIDDAM KAGFGWENGP FEIWDAVGVE KGIELMKAEG
     YEPAAWVTEM LASGTKSFYS VKDGATYFYS IPSKSAEKIP GQDAFIILNN IRESKKVWNN
     NESIITDLGD GVLNLEFTSK MNSIGAGVLQ GINKAVDMAE KGYNGLVIGN QDANFSVGAN
     LGMIFMLAVE QEYDEMNMAI KMFQDTMMRC RYSAIPVIAA PHGMTLGGGC ELTMHADRAV
     AAAETYIGLV EFGVGLIPGG GGSKEMALRA ADTFRKNDVE LNVLQEYFLT VGMAKVATSA
     YEGFDTGVLQ KGRDIVVVNK ERQIATAKQV ALQMAEQGYT QPAKRKDIKV LGKQALGMFL
     VGTDSMEAGK YISEHDKKIA NKLAYVMAGG DLSEPTLVNE QYLLDLEREA FLSLTTERKT
     LERIQHMLTK GKPLRN
//