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Database: UniProt
Entry: A0A1M6MXG0_9CLOT
LinkDB: A0A1M6MXG0_9CLOT
Original site: A0A1M6MXG0_9CLOT 
ID   A0A1M6MXG0_9CLOT        Unreviewed;       779 AA.
AC   A0A1M6MXG0;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SHJ88138.1};
GN   ORFNames=SAMN02745912_01466 {ECO:0000313|EMBL:SHJ88138.1};
OS   Paramaledivibacter caminithermalis DSM 15212.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Paramaledivibacter.
OX   NCBI_TaxID=1121301 {ECO:0000313|EMBL:SHJ88138.1, ECO:0000313|Proteomes:UP000184465};
RN   [1] {ECO:0000313|EMBL:SHJ88138.1, ECO:0000313|Proteomes:UP000184465}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15212 {ECO:0000313|EMBL:SHJ88138.1,
RC   ECO:0000313|Proteomes:UP000184465};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
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DR   EMBL; FRAG01000013; SHJ88138.1; -; Genomic_DNA.
DR   RefSeq; WP_073148455.1; NZ_FRAG01000013.1.
DR   AlphaFoldDB; A0A1M6MXG0; -.
DR   STRING; 1121301.SAMN02745912_01466; -.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000184465; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184465}.
FT   DOMAIN          7..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..307
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          477..654
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   779 AA;  87149 MW;  86DD191C6FD1456C CRC64;
     MDFNINKVAV LGAGVMGAGI AAHIVGAGIP VCLLDIVPRE LTEKEKAKGL TLDSPVVRNR
     FAQAGKDRVT NPKNRAIYDE AFGDMIEVGN FSDNMDVLKD CDWIIEVIVE NLEVKKNFMK
     QINKYRRLGS IVSSNTSGVS INKIVGDMPL EFRQHFLGTH FFNPPRYMKL FELIPGEHTL
     PEIVDFMTEF GTKKLGKGVV LAKDTPNFVG NRIGTYAIAN TIQLMEKYRY DIPKVDQLTG
     NVMGRPKSAT FRTLDMVGLD IFHHVAENVI NNIDDEAEKS EFNVPKFVVD LIENGQLGDK
     TKQGFYKKIK TERGKEILVW DRQKKEYVAL VKEKLEAINE ALKSSNKYET LVYGKREENK
     FAWEAIKNVL LYSARKIPEI TDNYKEIDNA MMWGFNWELG PFAIWDAIGL KKSVSRMKKE
     GEVIPEWIEE RLAANKVKFY DEVDFETPYI TISSPKNNIV KDNGHAALVD IGDDVLCLQF
     KTKGNTITDE VMDMIYDAVE EVQKNYKGLV IGNQSKNFSA GANLMLVGKL ASDKKWNELE
     DMVNKFQRAN MAIKYCKKPV VVAPYGMTLG GGAEITMHSH FVSAHAETYM GLVEVGVGLV
     PAGGGTKELL VRSIENLGKV NNGEMLSHIK KAWKNIATAK VSSSGYDAIK NGYMRKCDNV
     VMSKEYLIDE AKAKVLYLAE SGFRPLQKNT IKVLGTSGKA SLQYVIDFML KGGFISEYDA
     YIADKVAHIL TGGEVPAGID VTEEQILELE KEAFVSLCGE EKTLQRIGHM LNKGRPLRN
//
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