ID A0A1M6MXG0_9CLOT Unreviewed; 779 AA.
AC A0A1M6MXG0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SHJ88138.1};
GN ORFNames=SAMN02745912_01466 {ECO:0000313|EMBL:SHJ88138.1};
OS Paramaledivibacter caminithermalis DSM 15212.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Paramaledivibacter.
OX NCBI_TaxID=1121301 {ECO:0000313|EMBL:SHJ88138.1, ECO:0000313|Proteomes:UP000184465};
RN [1] {ECO:0000313|EMBL:SHJ88138.1, ECO:0000313|Proteomes:UP000184465}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15212 {ECO:0000313|EMBL:SHJ88138.1,
RC ECO:0000313|Proteomes:UP000184465};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FRAG01000013; SHJ88138.1; -; Genomic_DNA.
DR RefSeq; WP_073148455.1; NZ_FRAG01000013.1.
DR AlphaFoldDB; A0A1M6MXG0; -.
DR STRING; 1121301.SAMN02745912_01466; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000184465; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000184465}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..307
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 477..654
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 779 AA; 87149 MW; 86DD191C6FD1456C CRC64;
MDFNINKVAV LGAGVMGAGI AAHIVGAGIP VCLLDIVPRE LTEKEKAKGL TLDSPVVRNR
FAQAGKDRVT NPKNRAIYDE AFGDMIEVGN FSDNMDVLKD CDWIIEVIVE NLEVKKNFMK
QINKYRRLGS IVSSNTSGVS INKIVGDMPL EFRQHFLGTH FFNPPRYMKL FELIPGEHTL
PEIVDFMTEF GTKKLGKGVV LAKDTPNFVG NRIGTYAIAN TIQLMEKYRY DIPKVDQLTG
NVMGRPKSAT FRTLDMVGLD IFHHVAENVI NNIDDEAEKS EFNVPKFVVD LIENGQLGDK
TKQGFYKKIK TERGKEILVW DRQKKEYVAL VKEKLEAINE ALKSSNKYET LVYGKREENK
FAWEAIKNVL LYSARKIPEI TDNYKEIDNA MMWGFNWELG PFAIWDAIGL KKSVSRMKKE
GEVIPEWIEE RLAANKVKFY DEVDFETPYI TISSPKNNIV KDNGHAALVD IGDDVLCLQF
KTKGNTITDE VMDMIYDAVE EVQKNYKGLV IGNQSKNFSA GANLMLVGKL ASDKKWNELE
DMVNKFQRAN MAIKYCKKPV VVAPYGMTLG GGAEITMHSH FVSAHAETYM GLVEVGVGLV
PAGGGTKELL VRSIENLGKV NNGEMLSHIK KAWKNIATAK VSSSGYDAIK NGYMRKCDNV
VMSKEYLIDE AKAKVLYLAE SGFRPLQKNT IKVLGTSGKA SLQYVIDFML KGGFISEYDA
YIADKVAHIL TGGEVPAGID VTEEQILELE KEAFVSLCGE EKTLQRIGHM LNKGRPLRN
//