ID A0A1M6N5R0_9CLOT Unreviewed; 465 AA.
AC A0A1M6N5R0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Na+:H+ antiporter, NhaC family {ECO:0000313|EMBL:SHJ91065.1};
GN ORFNames=SAMN02745975_03208 {ECO:0000313|EMBL:SHJ91065.1};
OS Geosporobacter subterraneus DSM 17957.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Geosporobacter.
OX NCBI_TaxID=1121919 {ECO:0000313|EMBL:SHJ91065.1, ECO:0000313|Proteomes:UP000184536};
RN [1] {ECO:0000313|EMBL:SHJ91065.1, ECO:0000313|Proteomes:UP000184536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17957 {ECO:0000313|EMBL:SHJ91065.1,
RC ECO:0000313|Proteomes:UP000184536};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
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DR EMBL; FQZV01000052; SHJ91065.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M6N5R0; -.
DR STRING; 1121919.SAMN02745975_03208; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000184536; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF3; MALATE-2H(+)_NA(+)-LACTATE ANTIPORTER; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 157..449
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 465 AA; 50285 MW; 005BCBB6F57BC685 CRC64;
MERATIPRKH TVALLLIMVV SIAVCILSKT PLYIGLFLSV VWAMGICLKN GFQLPLLWNM
IIKGIKECSS IFIIILLVGS LVAIWLASGI VPAMMYYGFD YIQKMNFLLA GFFITMLTAM
VMGTALGTVS TIGVALLGIG KGLFIPEGLL MGAIISGAFI ADKISPIAAL VNLTTKTTGV
SYKDNARQGL ITLLPTIALV SYFYYYLGKG YNGELNSNQL YHYQEAIEEF FHISPLMLIV
PLIIIGMAFI GVKIIKNMTL GLLGGMIISY AYQNLGWAEI FRIILGGYSA GTSVEELNTI
IKGGGVASML EAILIVLAAV VLNSIFEGTN MIAPVIENFL LSIKSKRELI AKTGFLSILL
TILTCDQTVG ILLPGKFLKQ KYVEMGLPKS VLARTIGDTG VIVAPIIPWN VNAVLTTVIT
GVSALQYGPY AILCYVLPIV TLLFGASGFI RENENNHIEQ GMKIG
//
