ID   A0A1M6NLS5_9FIRM        Unreviewed;       434 AA.
AC   A0A1M6NLS5;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=O-acetylhomoserine (Thiol)-lyase {ECO:0000313|EMBL:SHJ96512.1};
GN   ORFNames=SAMN02745136_01351 {ECO:0000313|EMBL:SHJ96512.1};
OS   Anaerocolumna jejuensis DSM 15929.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Anaerocolumna.
OX   NCBI_TaxID=1121322 {ECO:0000313|EMBL:SHJ96512.1, ECO:0000313|Proteomes:UP000184386};
RN   [1] {ECO:0000313|EMBL:SHJ96512.1, ECO:0000313|Proteomes:UP000184386}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15929 {ECO:0000313|EMBL:SHJ96512.1,
RC   ECO:0000313|Proteomes:UP000184386};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; FRAC01000008; SHJ96512.1; -; Genomic_DNA.
DR   RefSeq; WP_073274162.1; NZ_FRAC01000008.1.
DR   AlphaFoldDB; A0A1M6NLS5; -.
DR   STRING; 1121322.SAMN02745136_01351; -.
DR   OrthoDB; 9780685at2; -.
DR   Proteomes; UP000184386; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:SHJ96512.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184386}.
FT   MOD_RES         210
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   434 AA;  48294 MW;  E746FB5614AE6474 CRC64;
     MATDRYQFDT QRLRAGYEPK EHNYAVSPPI YQTAAYDFRD VENAAGLFGL REPGFLYTRV
     GNPTVAVLEE RVRTLDKAAG IIALASGMAA ISYTLLNLAE GGGRILTSPY LYGGSTDSFK
     KIYPKFGIKF DYAKNIEDPE RLAEEIKPDT KAIFIESISN PNTVLLDIEA IAKVAHEHGI
     PLVVDNTVAT PYLYNPLAHG ADIVVYSATK GLNGHGNAIA GLVLEGGNFN YQTEKFPQFS
     EKYYTLRDID NKLRSFPEVF PDAPFTNRIR FNYLNYFGAA LSPFDAYLAL VGLETISERL
     SRQSRNALTL AEYLLKHPQV EWVRYPALKN SPHYGLYKRD FPKGAGGILS FGFKGTKEQR
     EAFLNSIELF HYHVNIGDAR SLIVNSPQTT HGELEAEEKK IADIPENLIR ISAGLEDAAD
     LIADLEQAFE KAVS
//