ID A0A1M6NTS4_9CLOT Unreviewed; 2606 AA.
AC A0A1M6NTS4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Amino acid adenylation domain-containing protein/thioester reductase domain-containing protein {ECO:0000313|EMBL:SHJ99034.1};
GN ORFNames=SAMN02745163_03011 {ECO:0000313|EMBL:SHJ99034.1};
OS Clostridium cavendishii DSM 21758.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121302 {ECO:0000313|EMBL:SHJ99034.1, ECO:0000313|Proteomes:UP000184310};
RN [1] {ECO:0000313|EMBL:SHJ99034.1, ECO:0000313|Proteomes:UP000184310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21758 {ECO:0000313|EMBL:SHJ99034.1,
RC ECO:0000313|Proteomes:UP000184310};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FQZB01000012; SHJ99034.1; -; Genomic_DNA.
DR STRING; 1121302.SAMN02745163_03011; -.
DR Proteomes; UP000184310; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000184310}.
FT DOMAIN 40..115
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1078..1153
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2110..2186
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2606 AA; 301640 MW; EDAB7CA08EE828AD CRC64;
MIPSYFMKLE NMPLNTNGKI DRNVLPSPDI DIVTGSVYEA ARNETEEALV KIWEEVLGVN
NIGINDNFFE LGGHSLKATI LVGRINKELE VEVPLKVIFD CENIKGLSEY ISVTSRKEYE
KIGKVEEKEY YEASSAQKRV YMLQELDKES TAYNIPGVIE IQGSLDLERL NKTFLKLIER
HETLRTSFET IDDNIIQKIH KMKSIEFKIE EIKAEDEAEI KDQINKFIQP FKLDKAPLLR
IGLIKIKKDR HILVFDMHHI ISDGISMRIL TKEFGAIYSG KELEKLKIQY KDYSEWQLKK
RRSEEFRRQE EYWLNEFREA IPVLNLPTDY KRPKIKNFKG SSIKFTLNKE MTRRLRNLAK
ETGTTMYMVL LASVNILLSK YSGQEEIIVG TPIAGRKHRD LENIIGMFVN TLVIRNNINA
KLSFKDYLKV IKEKALMAYE NQDYQFEDLV DKLEVVRDLS RNPLFDVMFV LQNMEESNVE
IENLIFRPYE QKNDVEKFDI TINAVEGMSK IYFTLSYATS LYKHETMERM AKHFINVIKE
ILRNIEVKID DINLLDQDEK NKLLIEFNKT VSDYPENKTI NELFEEEVNK NPNNIVAVFE
ENEITYKEFN EKANSLARIL RKKGIGPDDI VGIISEHSLN MIVGIMAVIK AGGAYLPIDP
YYPENRIEYI LNNSKAKIIL IQNKFKEKIK CEALIYDLDD EKLYKGDGTN LNKTANGSNL
AYLIYTSGTT GKPKGVMIEN KALINYALYA KEHYLNEQDV YMPLYTSIAF DLTITSIFAP
LISGNKIVIY EEKDINVLMK KVFQSNKEAV IKATPAHLSL LKEIPNINRK IKKIIVGGEE
LKEELSKKIS DIFHNQIEII NEYGPTEATV GCIAHKYNYR KEYDNTVFIG KPINNFHIYI
VDKKNKIVPI GIIGEICISG AGLARGYLKN KKLTEEKFIE NPYEIGQRMY KTGDLARWLP
DGNIEYLGRM DNQVKIRGFR IELGEIESTL LNIDGINEAV VLDNDKDGSN YLCAYYVAEK
EYSAEKLREK LKNLLPDYMI PSYFISLENI PLTKNGKVDK NSLPNPKDEI NIEVKYEKPK
NEIEEKLVKI WQDVLGVSKI GINDNFFDLG GHSLNATIVV SRISKQLNVE VPLREIFILG
TIKSLSKYIL LANKENYEKI PKAEEKEYYE ASSAQKRIYV LQQFDKESTA YNIPGAIEIK
GRLDIEKLNK TFSKLIERHE TLRTSFKTIN DDIIQKIHKI ESIKFKIEEI EVKDESEIRE
KVSDFIKCFD LSKAPLIRVG LIELKEDRYI LIFDMHHIIS DGISMGILTK EFGEIYGGKE
LEGLKLQYKD YSEWQNKIQQ KEEFKKQESY WLKEFEGEIP ILNMPTDYNR PLVQSFKGDS
IDFTIGKEET KILREIARES GSTMYMVLLS AFKVLLSKYS GQEEIIVGTP IAGRYHSDLE
NIIGMFVNTL AIRSTINEED TYEDYLYKIK DKLFSAYENQ DYQLENIVEK VNVKRESNRN
PLFDIAFTMQ NMDSGLIKID ELKFRKYNLG DNTAKFDITM TAVEINDCIY LNLCYATKLY
RKETIERFKE SYLAIVAQII INRRLKIKDI KIISEKETEK ILLNFNNTKV NYKRNKTIQE
LFEEQVLKTP NNIVVIFGDK KLTYNELNQK ANSLARILRE KGVEQDVIVG IMPERSIEMV
VGIMAILKAG GAYLPIDIQY PKDRIIYMLK DSNVKILLEQ NSSIDITGLK CEVLNLNNDK
LFNSNNNNNL KILNHSNDMA YIVYTSGTTG KPKGVIIEHE GIVNLSNFFT NDLKISSDKK
ILQFASIAFD AFSWELYMAI LCGAELHIIP KEVSMNMLLL NNYIKRNELN ILTLPPFIAD
KIDINDSKIQ LVITAGSEVK KVLVNKLCKK VKYINAYGPT ESTICTTIWR YEKNLNDTVP
IGKPINNIRV YIMDKNNNLQ PIGVPGELCI SGDGLARGYL NRPELTSEKF IENPYKIGER
IYKTGDLARW LPDGNVEFLG RIDHQVKIRG FRIELGEIET RLLEIEGIKE VTVLANDNDE
NKFLCAYYVG ERRYTVSEFR SILNNSLPEY MIPSYFIKLE SMPLNTNGKI DRKALPNPED
DILTSSVYEA PRNDMEEKLV AIWSKFLKVS NIGINDNFFE LGGNSLKAIQ LTIAMNSDFD
VEVNDIFKNQ TIKNLAQNIS YNKGKLKKQI QKIKDIIVSK DKLNNYDFNE LRKEAYLKYN
ERCILDRKIN LEQRKYYKNI LLIGATGYLG IYILKTLLET SNSNIYLIIR GRDNKEAEKR
LIEKFEYYFD EKIYGDYSQR INVLCGDITK NEFGLDYLDY NRLTKTIDCV LNSAANVKHY
GNYEDFYDIN VLAVSNLLEF CYQNKKKDFN HISTLSVGSG HIENSKYRLF TEFDIDENQI
IKNYYIKSKL EAEKLILKAR QKGINTNIFR VGNLVFDSTS GRFQKNIEDN NFYEFIKSLI
EFGSYPGFGA FYYDFSFIDH TAKAITLLFN VIELSNQVYH ISNPNKISLV NVCELIQKYE
PNFKKRKTED FLNELYLSFE NNSFKYNISK IIMNLNILGD GRETTNFEIT SKRTNDLLKK
VGFSWDIVDE IHIKRMIDHC KKIGYI
//
