ID A0A1M6NXZ7_9BACL Unreviewed; 744 AA.
AC A0A1M6NXZ7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN ORFNames=SAMN05443507_10722 {ECO:0000313|EMBL:SHK00619.1};
OS Alicyclobacillus montanus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Alicyclobacillus.
OX NCBI_TaxID=1830138 {ECO:0000313|EMBL:SHK00619.1, ECO:0000313|Proteomes:UP000184016};
RN [1] {ECO:0000313|Proteomes:UP000184016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USBA-503 {ECO:0000313|Proteomes:UP000184016};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
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DR EMBL; FRAF01000007; SHK00619.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M6NXZ7; -.
DR STRING; 1830138.SAMN05443507_10722; -.
DR Proteomes; UP000184016; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000184016}.
FT DOMAIN 15..294
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 295..577
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 744 AA; 84860 MW; 98C10808551C36D2 CRC64;
MFMHKMGIGS ERILDGLNPA QLEAVQATEG PLLILAGAGS GKTSVLTRRI AYLLGHCRVS
PWNVLAITFT NKAAREMRER IEQWVGLAGQ DVMASTFHSF CAKILRRDID QMGYSTRFTV
LDSSDQIAIV RKILRDYQID SKRFDPRAVL GGISQHKNAL VNPQKAKDGA RDLFSRIVAD
TYIEYERRLK LNEALDFDDL IMKTVELFRA VPEVRSAYSQ KYRYIHVDEY QDTNHAQYIL
IRLLADEHRN LCAVGDSDQS IYGWRGADIR NILQFEKDFP EAKVIRLEQN YRSTQTILDI
ANHVIRNNRD RQEKTLWTDG EKGEAAQLLE CRDERVEAAW ISQELVKWVE AGGQYTDAAV
LYRTNAQSRV IEETFLQRGI PYRIYGGVRF YERKEIRDLI AYLRLIDNPA DDASFLRIVN
VPKRGIGDTS LGRLAEYANA HQMPLLAACE HLEAAGLSGK AKMGLTSFAE WMEECHEQQK
KLSVTEITRL IIEQTKYVEM LQTEHSLEAE SRIENLEEFL SLTKEFDENW PGLEPVERLS
QFLTDVSLVA DTDMDNGRPS PESAQGVTLM TLHSAKGLEF PIVFLIGMEE GIFPHSRSFN
SEEELEEERR LCYVGVTRAR KRLYLSTCAT RMIFGDVHSY TPSRFLKEMP VHCLQRISPG
QPSEKRELWR PRSSGLLQQI PSSFGADLSV EYHVGDRVLH RKWGQGVILS TSGSGEDMEM
TVHFPAPIGE RKLAARFAPI RKSE
//
