ID A0A1M6T1N8_9AQUI Unreviewed; 681 AA.
AC A0A1M6T1N8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=SAMN05444391_1259 {ECO:0000313|EMBL:SHK50819.1};
OS Thermocrinis minervae.
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Thermocrinis.
OX NCBI_TaxID=381751 {ECO:0000313|EMBL:SHK50819.1, ECO:0000313|Proteomes:UP000189810};
RN [1] {ECO:0000313|EMBL:SHK50819.1, ECO:0000313|Proteomes:UP000189810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19557 {ECO:0000313|EMBL:SHK50819.1,
RC ECO:0000313|Proteomes:UP000189810};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
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DR EMBL; LT670846; SHK50819.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M6T1N8; -.
DR STRING; 381751.SAMN05444391_1259; -.
DR OrthoDB; 9764149at2; -.
DR Proteomes; UP000189810; Chromosome i.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00357; CSP; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 2.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000189810};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 600..681
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 681 AA; 78820 MW; 1A2533871AFC423F CRC64;
MEDLILELFK KAKRPLHFME IAQRLGLEKK QLKALKKALR NLKKKHLLQV VKGRYVLASE
PIVKGTVIAF PAGFGFLHVG EGQKDIYIPP FEMQKLFSGD VIKAKVVEYK GKKEVRVLKI
LKRAKKDIVC KIEGMYAIPV DENSFHKIVL VKKDRNKLKD GTYVVVEIIS YPSKGNPAIG
RIKEVLGHPS ERSLIVELLI RKYELPTDYP PAVKKEAESL TILIKEDRRD LRDQVCFTID
PERARDFDDA VAIEKIDQER FRLWVHIADV TYFVKLGSEI DKEAYRRGFT FYLPDRALHM
LPERLSADLC SLKPNEDRLA FTCQMTFDLK GRLLDYDLYE SVIKSKARLT YNEALSLIVG
DPALENKYPG FVEHLRLMED LYRILSKKRW ELGSIDFDLP EVELIVDEYG EPTAIIPYER
HVAHRIIEQF MVSANETVAM HLENAGYPCL YRVHEKPDPE KVENLLEILN GLGYKTKGFS
LEPRFFQKII EYFEGRPEEN LVRFLTLRSM KRAVYSPHNL GHFGLASEHY AHFTSPIRRY
PDIVVHRLLK DSLMGREPTY DIEELEQMGQ YLSMREWLAE EVERTAIDLL KARYMKAHVG
EVFEGIITGL IPAGFFVEIK EYLVEGLVKI SDLTDDEYIY DEPAHRFVGV RTGKVYRLGD
VVRVKVVAVD EERGKLELVL V
//
