ID A0A1M6UH37_9BACT Unreviewed; 458 AA.
AC A0A1M6UH37;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=SAMN05720762_102506 {ECO:0000313|EMBL:SHK68398.1};
OS Fibrobacter sp. UWH4.
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=1896210 {ECO:0000313|EMBL:SHK68398.1, ECO:0000313|Proteomes:UP000184331};
RN [1] {ECO:0000313|EMBL:SHK68398.1, ECO:0000313|Proteomes:UP000184331}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWH4 {ECO:0000313|EMBL:SHK68398.1,
RC ECO:0000313|Proteomes:UP000184331};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; FRAY01000002; SHK68398.1; -; Genomic_DNA.
DR RefSeq; WP_072978031.1; NZ_FRAY01000002.1.
DR AlphaFoldDB; A0A1M6UH37; -.
DR STRING; 1896210.SAMN05720762_102506; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000184331; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:SHK68398.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SHK68398.1}.
FT DOMAIN 3..271
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 304..453
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 458 AA; 50904 MW; CA64860F6E0F9D8F CRC64;
MINLILCGGS GTRLWPVSRS LMPKQFAPLF DGQSLFRKTV VTNSAVCESQ FIVSNADQFF
LAKDQLEMEG MTGSKFLLEP VGRNTAPAIA LACLTMDPET IVLVSPSDHV IRKKDEYKKV
LLRAQELAET GNFVTFGITP TSPETGYGYI EAAGEDVKRF VEKPDLATAE KYLLSGNFYW
NSGIFCFKAK TFLAELGKYS PKMLATAQKA LSNATVEDGE PIRIDRDDMM AIPSNSIDYA
VMEKSSKVKV VPSDIGWSDL GSFDSLYNEY PHDDNGNNVN PRHIAVGSRN SLVMGSQRAI
ATIDLDKMLI VDTPDALLVA PLSSSQKVKK VVEELKQRGS DLINVPQTVS RPWGTYSVLE
STERYKMKRI VVKPGKRLSL QKHLHRSEHW VVVSGTATVT VGKNVFYVRP NESTYIPVGE
VHRLQNEGKL PLVIVEVQVG EYTGEDDIIR MEDDFHRN
//