ID A0A1M6UUI5_PSETH Unreviewed; 542 AA.
AC A0A1M6UUI5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=3-oxosteroid 1-dehydrogenase {ECO:0000313|EMBL:SHK72771.1};
GN ORFNames=SAMN05443637_11116 {ECO:0000313|EMBL:SHK72771.1};
OS Pseudonocardia thermophila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1848 {ECO:0000313|EMBL:SHK72771.1, ECO:0000313|Proteomes:UP000184363};
RN [1] {ECO:0000313|EMBL:SHK72771.1, ECO:0000313|Proteomes:UP000184363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43832 {ECO:0000313|EMBL:SHK72771.1,
RC ECO:0000313|Proteomes:UP000184363};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; FRAP01000011; SHK72771.1; -; Genomic_DNA.
DR RefSeq; WP_073457746.1; NZ_FRAP01000011.1.
DR AlphaFoldDB; A0A1M6UUI5; -.
DR STRING; 1848.SAMN05443637_11116; -.
DR OrthoDB; 9813348at2; -.
DR Proteomes; UP000184363; Unassembled WGS sequence.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000184363}.
FT DOMAIN 5..515
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 542 AA; 56575 MW; 7BF42F54796DD0A5 CRC64;
MTDADVVVVG AGMGGMAAAV TAAERGLRVV LLEKGAKVGG AAAYSGGQVW VGNNHVAARD
GIADSAADTL AYVTAAASRD ASSLDRRLAE QWIAAAATAA RWFEDIGVIT WEVIPGYPDY
YYPDLPGSRA AGRYLTGAPF DGRRLGADRE RLLVSPHFPV GIQYGEMFAW GGMSSRTEWD
WDLVAQRRAD DVLTFGTGVA AAFFRGVLDR GVDVRTGHEV IGLVVRDGAV TGVRVRGPEG
ETTISGQVVL CTGAHDWSAE LSAKFTGIPD DDGGSVAPNT VTGDAIALVE PVGATPAALP
AWAAPVLPGY RLAEPAFDGD TGYRACFEHC LPHTFLVNAR GERFCDDAFH PRIVAAALGD
EQGGNLPFFM IWDSRHHRKY GLGATPPGGE YPAGLVASAP TLRELAVQLG IPGDALETTA
ARFNEHAVAG EDPQFGRGTN LSVRLFRGDG RHAANPNVGP VDEPPFFGMR MRLLNTGIAA
AGVRTGEHGR VLDGAGAPIP GLFAAGECAT RAAAGVGYNS GYSLSRAMAF GFLAASAIAD
AR
//
