ID   A0A1M6V4X1_9FIRM        Unreviewed;       616 AA.
AC   A0A1M6V4X1;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SHK76444.1};
GN   ORFNames=SAMN02745123_03046 {ECO:0000313|EMBL:SHK76444.1};
OS   Desulforamulus aeronauticus DSM 10349.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC   Desulforamulus.
OX   NCBI_TaxID=1121421 {ECO:0000313|EMBL:SHK76444.1, ECO:0000313|Proteomes:UP000183997};
RN   [1] {ECO:0000313|EMBL:SHK76444.1, ECO:0000313|Proteomes:UP000183997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10349 {ECO:0000313|EMBL:SHK76444.1,
RC   ECO:0000313|Proteomes:UP000183997};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FRAR01000023; SHK76444.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M6V4X1; -.
DR   STRING; 1121421.SAMN02745123_03046; -.
DR   Proteomes; UP000183997; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        41..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        65..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        103..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          283..566
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   616 AA;  69045 MW;  1769A9D6E34BD4C1 CRC64;
     MNQLRIPILM FCDALLINLS IIIPCLVHCH GKIPQEIFNK NIEFSLFLTP VVLGIFYSSR
     LYHRIWTYAS MGELITIIKA ISMGVLAIVT ISYFGNATII QEVILSVWVY SIVLIGGSRF
     AWRLYVERNN KRKYPLTKAG KKVLIYGAGS AGALVAREYE NHYNGKLPVI GFIDDDPAKH
     HLKIYGLPVF GDRKIIPTLV SEYCVEEIII AMPSVSGKEV REIIEFCKEI VGEVKILPGV
     YQFLNGNVSI NKIRPVDIED LLGREPVQIN LEEISHYLKR KVVLITGAGG SIGSELCRQI
     AQVDPEKIIL LGHGENSIHK IWLELRDKFP LLPLEIEIAD VRDRFKLELV FVKHRPHVVF
     HAAAHKHVPL MEMHPDEAIK TNVFGTKYVA EMADRFRVER FVLISTDKAV NPSSVMGATK
     RIAELIIQNL FKHSETKFAA VRFGNVLGSS GSVVPIFKEQ VAKGGPVTLT HPGMTRYFMT
     IPEAVQLVIQ AGAMAEGGEV FLLDMGEPVK IVDLAANLIK LSGLEPGKDI EIKVTGIRPG
     EKLFEELLTA EEGSSSTKHK RIFIAKPVEV DEAVLLYELL KLSKREVTDA DEIFARLEKL
     MPKMIDYRAK KDRLAI
//