ID A0A1M6XJY6_PSETH Unreviewed; 305 AA.
AC A0A1M6XJY6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:SHL06169.1};
GN ORFNames=SAMN05443637_11740 {ECO:0000313|EMBL:SHL06169.1};
OS Pseudonocardia thermophila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1848 {ECO:0000313|EMBL:SHL06169.1, ECO:0000313|Proteomes:UP000184363};
RN [1] {ECO:0000313|EMBL:SHL06169.1, ECO:0000313|Proteomes:UP000184363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43832 {ECO:0000313|EMBL:SHL06169.1,
RC ECO:0000313|Proteomes:UP000184363};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
CC -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC family. {ECO:0000256|RuleBase:RU003523}.
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DR EMBL; FRAP01000017; SHL06169.1; -; Genomic_DNA.
DR RefSeq; WP_073458863.1; NZ_FRAP01000017.1.
DR AlphaFoldDB; A0A1M6XJY6; -.
DR STRING; 1848.SAMN05443637_11740; -.
DR OrthoDB; 9784013at2; -.
DR Proteomes; UP000184363; Unassembled WGS sequence.
DR GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:SHL06169.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000184363};
KW Transferase {ECO:0000256|RuleBase:RU003523}.
FT DOMAIN 6..273
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 305 AA; 31355 MW; 4CA40B03D89A4F81 CRC64;
MSAPTVEIVE VALRDGLQNE PVVLPTADKL RLLDGLLAAG ARRLEIASFV HPRLVPAMAD
AEAVLAGARR LPGVTYAGLV LNRRGLERAL AAGVDEIDVV VCASDTFSRR NQNAGTEESM
AEALEIVADA RAAGLAATVT IATAFGCPFE GEIDPARVLG LARRALDAGA GEIAFADTIG
CGVPDQVAHL ASAVREWGNP AGLRFHFHNT RNTGYANAWA AVEHGATALD ASVGGIGGCP
FAPRATGNVA TEDLAYLLAR SGLATGLDLD ALCALSGTVG ELLGKQVPAL LPRAGTFPPS
RVDVP
//
