ID A0A1M6XUU8_9BACT Unreviewed; 324 AA.
AC A0A1M6XUU8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Arginase {ECO:0000256|ARBA:ARBA00018123, ECO:0000256|RuleBase:RU361159};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168, ECO:0000256|RuleBase:RU361159};
GN ORFNames=SAMN02746009_02094 {ECO:0000313|EMBL:SHL09633.1};
OS Hymenobacter psychrotolerans DSM 18569.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1121959 {ECO:0000313|EMBL:SHL09633.1, ECO:0000313|Proteomes:UP000183947};
RN [1] {ECO:0000313|Proteomes:UP000183947}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18569 {ECO:0000313|Proteomes:UP000183947};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000227,
CC ECO:0000256|RuleBase:RU361159};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361159};
CC Note=Binds 2 manganese ions per subunit.
CC {ECO:0000256|RuleBase:RU361159};
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742, ECO:0000256|RuleBase:RU361159}.
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DR EMBL; FRAS01000010; SHL09633.1; -; Genomic_DNA.
DR RefSeq; WP_073284243.1; NZ_FRAS01000010.1.
DR AlphaFoldDB; A0A1M6XUU8; -.
DR STRING; 1121959.SAMN02746009_02094; -.
DR OrthoDB; 9788689at2; -.
DR Proteomes; UP000183947; Unassembled WGS sequence.
DR GO; GO:0004053; F:arginase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09989; Arginase; 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR014033; Arginase.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR NCBIfam; TIGR01229; rocF_arginase; 1.
DR PANTHER; PTHR43782; ARGINASE; 1.
DR PANTHER; PTHR43782:SF3; ARGINASE; 1.
DR Pfam; PF00491; Arginase; 1.
DR PIRSF; PIRSF036979; Arginase; 2.
DR PRINTS; PR00116; ARGINASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503,
KW ECO:0000256|RuleBase:RU361159}; Hydrolase {ECO:0000256|RuleBase:RU361159};
KW Manganese {ECO:0000256|RuleBase:RU361159};
KW Metal-binding {ECO:0000256|RuleBase:RU361159}.
SQ SEQUENCE 324 AA; 36241 MW; BCC6F164FF14BEC6 CRC64;
MRRIKLLEVR SELGAGTRGA SMGVDALKVA CLNKGSDYFR RFNSVNVPDL NHVLFEKNHF
PKAKHIDSVY TVQKNIASTV EQTLRFGEFP LVLAGDHSNA SGTIAGIKAA YPHKTLGVVW
IDAHADIHSP YTTPSGNMHG MPLSISLGDD NRECQRNQPE PETEFFWQKL KNLGEPGPKI
APEHLVYVVV RDTEAEEDAV IERLGIKNYK LDEVKAKGTR QVAREIYERL RFCDMVYISF
DVDSLDSRFS KGTGTPVVDG LNVEEAISLC RALLDNDRVV CFEMVEINPT LDNMNTMATN
AFDILEAATD AIQNRLRMEE VVSR
//
