ID A0A1M6YEH5_9BACT Unreviewed; 439 AA.
AC A0A1M6YEH5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Histidine--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00127};
DE EC=6.1.1.21 {ECO:0000256|HAMAP-Rule:MF_00127};
DE AltName: Full=Histidyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00127};
DE Short=HisRS {ECO:0000256|HAMAP-Rule:MF_00127};
GN Name=hisS {ECO:0000256|HAMAP-Rule:MF_00127};
GN ORFNames=SAMN05720762_104369 {ECO:0000313|EMBL:SHL16523.1};
OS Fibrobacter sp. UWH4.
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=1896210 {ECO:0000313|EMBL:SHL16523.1, ECO:0000313|Proteomes:UP000184331};
RN [1] {ECO:0000313|EMBL:SHL16523.1, ECO:0000313|Proteomes:UP000184331}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWH4 {ECO:0000313|EMBL:SHL16523.1,
RC ECO:0000313|Proteomes:UP000184331};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00127};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC Rule:MF_00127}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00127}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00008226, ECO:0000256|HAMAP-Rule:MF_00127}.
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DR EMBL; FRAY01000004; SHL16523.1; -; Genomic_DNA.
DR RefSeq; WP_072978927.1; NZ_FRAY01000004.1.
DR AlphaFoldDB; A0A1M6YEH5; -.
DR STRING; 1896210.SAMN05720762_104369; -.
DR OrthoDB; 9800814at2; -.
DR Proteomes; UP000184331; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00773; HisRS-like_core; 1.
DR Gene3D; 3.40.50.800; Anticodon-binding domain; 1.
DR HAMAP; MF_00127; His_tRNA_synth; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR015807; His-tRNA-ligase.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR NCBIfam; TIGR00442; hisS; 1.
DR PANTHER; PTHR43707:SF1; HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43707; HISTIDYL-TRNA SYNTHETASE; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF52954; Class II aaRS ABD-related; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00127,
KW ECO:0000313|EMBL:SHL16523.1};
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00127};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00127};
KW Ligase {ECO:0000256|HAMAP-Rule:MF_00127};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00127};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00127}.
FT DOMAIN 1..332
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 439 AA; 48901 MW; 0281F6C33AA56D6A CRC64;
MSISIPQLPK GTRDFYPEAE RIQNYIFDTW RSVAESFAYE EYEGPMFEHL ELYTGKSGEE
IVSQLYNFKD KGDREIALRP EMTPTLARLV IQKARELKKP FKWFSMPRLF RYEKAQKGRL
REFFQLNMDI IGTESIYAEA DLMAAIATML RKFGLKDGEF AIGVSSRKLL ATYLEEIGAP
NPALVYPVLD RRLKIGPEAF AKALADAGLS EDQVKKLDDF MSCKSIEEVK AKVHSENATA
ALAEIEDLFA TLTAAGYGEC VNLDLSIVRG LAYYTGIVFE VFDKGKSMRA IAGGGRYDSL
TEKLGGERIP GVGFGMGDVV LADLLAEHKL LPSPKQSVDF YIASFTNDMK KVFETAQVFR
NAAGNTNAKP FSVAHPLAAM KMGKQLDQAN YQGAKIVVYV DGSKAAEGEF EYKDMRTGEM
FVGNVDAIVE RLNTEVKKA
//
