ID   A0A1M6YES1_9FLAO        Unreviewed;       481 AA.
AC   A0A1M6YES1;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=23S rRNA m(5)U-1939 methyltransferase {ECO:0000313|EMBL:SHL16814.1};
GN   ORFNames=SAMN05444484_101549 {ECO:0000313|EMBL:SHL16814.1};
OS   Flavobacterium chilense.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=946677 {ECO:0000313|EMBL:SHL16814.1, ECO:0000313|Proteomes:UP000184028};
RN   [1] {ECO:0000313|EMBL:SHL16814.1, ECO:0000313|Proteomes:UP000184028}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24724 {ECO:0000313|EMBL:SHL16814.1,
RC   ECO:0000313|Proteomes:UP000184028};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01024}.
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DR   EMBL; FRBT01000001; SHL16814.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M6YES1; -.
DR   STRING; 946677.SAMN05444484_101549; -.
DR   Proteomes; UP000184028; Unassembled WGS sequence.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.40.50.1070; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR030390; MeTrfase_TrmA_AS.
DR   InterPro; IPR030391; MeTrfase_TrmA_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   NCBIfam; TIGR00479; rumA; 1.
DR   PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11061:SF30; TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01230; TRMA_1; 1.
DR   PROSITE; PS01231; TRMA_2; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01024};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01024};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01024}.
FT   DOMAIN          14..75
FT                   /note="TRAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50926"
FT   ACT_SITE        439
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT   ACT_SITE        439
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         313
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         342
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         363
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         412
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ   SEQUENCE   481 AA;  55218 MW;  8FC82D1E0F30045F CRC64;
     MKKFTNPYFC AMGRKNTDKI VFHQIQVLDA GAKGVSVAKA PDGKVIFIPN VVPGDVVDVQ
     TFKKRKAYYE GKAVKFHELS EHRIDPICDH FGVCGGCKWQ NMKYSQQLYY KQNEVKNHLQ
     RIGKVELPEF ETILGSEKQF FYRNKMEFSF SNSRWLTEKE IGSTEDLGNR NALGFHIPKM
     WDKILDINKC HLQEDPSNAI RNEIRAFAND HNLAFFNPRE HSGLLRTLMI RTASTGEIMV
     LIQFFEDDKE NRELVLDHLY EKFPQITSLQ YVVNAKQNDT IYDQDIKLYK GRDYILEEME
     GLKFSINAKS FYQTNSDQAY ELYKITRDFA GLSGNETVYD LYTGTGTIAQ FVSKKAKKVI
     GVESVPEAIL DAKANAERNN ITNCEFFVGD MKVVFNESFI AQHGKPDVII TDPPRDGMHA
     AVIDQILKIA PKKVVYVSCN SATQARDLAL MDEKYKVTRV RPVDMFPQTH HVENVVLLEL
     R
//