ID A0A1M6ZD14_PSETH Unreviewed; 607 AA.
AC A0A1M6ZD14;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:SHL28245.1};
GN ORFNames=SAMN05443637_12347 {ECO:0000313|EMBL:SHL28245.1};
OS Pseudonocardia thermophila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1848 {ECO:0000313|EMBL:SHL28245.1, ECO:0000313|Proteomes:UP000184363};
RN [1] {ECO:0000313|EMBL:SHL28245.1, ECO:0000313|Proteomes:UP000184363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43832 {ECO:0000313|EMBL:SHL28245.1,
RC ECO:0000313|Proteomes:UP000184363};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FRAP01000023; SHL28245.1; -; Genomic_DNA.
DR RefSeq; WP_073459797.1; NZ_FRAP01000023.1.
DR AlphaFoldDB; A0A1M6ZD14; -.
DR STRING; 1848.SAMN05443637_12347; -.
DR OrthoDB; 5241017at2; -.
DR Proteomes; UP000184363; Unassembled WGS sequence.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:SHL28245.1};
KW Cell division {ECO:0000313|EMBL:SHL28245.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000184363};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..607
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038793395"
FT DOMAIN 33..142
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 330..600
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 607 AA; 62149 MW; D11D931F0C387E50 CRC64;
MRARTSTALL ALLLSALLVL ATAAGCGLLG SKAGDAAEEF ARAWTAGDDQ AAAALTDDPS
AAAAVLRRTR EALAPTGLSV TVGQVREATG RATASIDVTW TLGPDRTWQY LGSIDLVAAP
DTEHGWLVRW APSVVHPDLG ARQRLAFSTT PAEPGPVLDR EGAPLLTATP VVTVLLDRTA
TGNLPAVTGA LAAALRTIDD RITQESITQG AARTPDGQAY PVAVLRRPDY ERVKSAIHDL
PGVRFTSSDR LLGPAPAFGQ QVLPGVRTEM AAQLEGVPGW AVRVVDEAGT TVKTLVEQPP
KPGTAVSTGL DRTLQAAAED AVEPLPQQAM LVAVSASTGD VLAVAQNGAA DLAGALALTG
RYPPGSTFKI ATAAAAVGAR GLTADSPVPC PEQTVIGGRA VPNDDRFDLG TVSLRTAFAR
SCNTTFAQLG AELGADALPT AARTLGLGAD YTIPGIVTVT GSVPATADEV LRAENGFGQG
RVLASPFGMA LVAATVAHGA PVVPQLIRGR PTLVSVPATE PDPAVLDQVR ALMRAVVTEG
TATRLAGSGE VYGKTGTAEF EQQGRRGAHG WFAGYRGDVA FAVLVVDAGS SAPAVEVAAR
FLEAAER
//
