ID A0A1M7FLZ9_9BACT Unreviewed; 882 AA.
AC A0A1M7FLZ9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN ORFNames=SAMN02746009_03861 {ECO:0000313|EMBL:SHM05005.1};
OS Hymenobacter psychrotolerans DSM 18569.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1121959 {ECO:0000313|EMBL:SHM05005.1, ECO:0000313|Proteomes:UP000183947};
RN [1] {ECO:0000313|Proteomes:UP000183947}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18569 {ECO:0000313|Proteomes:UP000183947};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity.
CC {ECO:0000256|ARBA:ARBA00002835, ECO:0000256|RuleBase:RU362085}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU362085};
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
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DR EMBL; FRAS01000031; SHM05005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M7FLZ9; -.
DR STRING; 1121959.SAMN02746009_03861; -.
DR Proteomes; UP000183947; Unassembled WGS sequence.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR GO; GO:0030908; P:protein splicing; IEA:InterPro.
DR CDD; cd00984; DnaB_C; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007692; DNA_helicase_DnaB.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR007868; Hom_end_hint.
DR InterPro; IPR007869; Homing_endonuc_PI-Sce.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00665; DnaB; 1.
DR PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF03796; DnaB_C; 2.
DR Pfam; PF05204; Hom_end; 1.
DR Pfam; PF05203; Hom_end_hint; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS51199; SF4_HELICASE; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU362085};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW Helicase {ECO:0000256|RuleBase:RU362085, ECO:0000313|EMBL:SHM05005.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362085}; Primosome {ECO:0000256|RuleBase:RU362085};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 207..244
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT DOMAIN 365..500
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 587..824
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT REGION 840..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..882
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 882 AA; 98239 MW; 756D823C596C5DBB CRC64;
MNDRMDDRLK LSASRAKAAW NSRPTPALPM GGPAGKLPPQ ALELEAAVLG ALMLEKDALT
TVIDILKPQS FYKDGHQRIF KAILNLFDKS EPIDILTVTH ELREMGELEA AGGAHYVANL
TFKVNSAANI EYHSRIITEN AIKRELINIA STIQRDAFED TTDVFNLLDS TEQALFEVSE
SNIRKNFDDM RSLMGKAIKE LEEKKDQKDG LTGVPSGFSA LDRVTSGWQP SDLVIIAARP
GMGKCLGKGT KVLMYDGTLR KVEDVREGEL LMGDDSMPRR VLNIARGREN MYWVRQNKAE
AYRVNESHIL SLKRSRTEGP HRHGDVLNIT VKDWLGKSDK FRSNYKGYKV PVEFAAREVP
VDPYFLGVWL GDGASDNCRI TGQDPEIIEY LHQYAAELDM QVTVGVVADR CNSYGITRGR
QGGSIAQYSL QDELRQLGVL GDKHIPQQYL SNSTENRLRL LAGLIDSDGH LDPVSNGYEI
TQKNHRLARQ IKFLADSLGF RTSLKKKRAT ISRSGYESEV YRVRIYGDIN RVPVRVARKK
AQPWKSPIDW RMTGIAVEFD QVDDYYGFAI DGNRLFLLQD MTVTHNTAFV VSAMRNAAVE
FKKPVAIFSL EMSSLQLVNR LISAEAELDS EKIKKGNLAD YEWAQLNHKI SSLSSAPIYI
DDTPGLSIRE LRTKCRRLKA HHDIQMIIID YLQLMTGNTD GKGGGGNREQ EIASISRALK
GIAKELNVPV LALSQLSRSV ETRGGDKKPQ LSDLRESGSI EQDADMVIFL YRPEYYKITE
DEMGNPTQGT GEVIIAKHRN GSLETVQLKF IGKFTKFADL DGAGGFGDAG FNPGAFPTST
FDDDPSAFAP NTIRLGSRIN NDGPPPAQPF PRSNFDDGPP PF
//
