ID A0A1M7FZR0_9SPHI Unreviewed; 797 AA.
AC A0A1M7FZR0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=SAMN05216524_101785 {ECO:0000313|EMBL:SHM09513.1};
OS Mucilaginibacter sp. OK098.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1855297 {ECO:0000313|EMBL:SHM09513.1, ECO:0000313|Proteomes:UP000184158};
RN [1] {ECO:0000313|EMBL:SHM09513.1, ECO:0000313|Proteomes:UP000184158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK098 {ECO:0000313|EMBL:SHM09513.1,
RC ECO:0000313|Proteomes:UP000184158};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; FRCM01000001; SHM09513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M7FZR0; -.
DR STRING; 1855297.SAMN05216524_101785; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000184158; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 69..228
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 311..571
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 704..792
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 797 AA; 89451 MW; 0BF0E44F96BF41F9 CRC64;
MRPGLNRIKS YLKKPKVIII LAFLLTLFLL FWFCLPKPLF NSPTSYVIDD TDGQLLGASI
ATDGQWRFPP NAEVPEKFKQ CIIAFEDKRF MHHPGFDILA LGRAIKQNFH SSKITSGGST
ITMQVIRLAT RHKRNIWNKL IEMFMAVRLE AGYSKNEILS FYTSNAPFGS NVIGLDAASW
RYFGRSPDKL SWGEMAAMAV LPNAPSLVHP GRNRAILLKK RNLLLDKLYH QGVIDSITAA
LAKFEPVPDR PMPLPQLAPH LLERFKSDHQ TNTHGDTRLR TSIRSSLQQQ VNEILERHHQ
VLKSNEINNI AAVVLDVETG AALAYAGNIA HPEDPEMESD VDVVDAPRSP GSTLKPMLYA
SMLQDGLLLP NSLMPDIPTQ IAGYHPENFD LGYDGAVPAS RALSRSLNVP AVKMLQQFKY
ERFYGVLQKM GITTLKKPAD HYGLSLILGG GENTLWELSG AYADMARVLN HYTKYNGKYD
PTDYHNPVYS VSSRKNKPEF EKSGLLDAGS IYYTLQAMEE VMRPGEEMLW QQFSSSQRVA
WKTGTSFGFR DGWAIGITPK YVVGVWVGNT DGEGRPNLTG ISTAAPALFE IFRLLPVTRD
WFEMPVGEMV KIKVCHQSGY RAGEYCDDTD DLWVPKSGLK APVCPYHQLV HLSADGKWQV
TGNCTPPNQI INKHWFVLPP SMEYYYKTKN YQYRVLPPFR PDCVQAENAA PMEVIYPKDG
AKIYVPLEAD GSRGRVIFNA AHRQSGVKIF WHLDDKYVGE TKDFHQMALN PPPGKHVLTL
VDGNGNTVHI GFEVLAK
//
