ID A0A1M7GW62_9GAMM Unreviewed; 788 AA.
AC A0A1M7GW62;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Small conductance mechanosensitive channel {ECO:0000313|EMBL:SHM20470.1};
GN ORFNames=SAMN05878437_1763 {ECO:0000313|EMBL:SHM20470.1};
OS Halomonas subglaciescola.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=29571 {ECO:0000313|EMBL:SHM20470.1, ECO:0000313|Proteomes:UP000190911};
RN [1] {ECO:0000313|EMBL:SHM20470.1, ECO:0000313|Proteomes:UP000190911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACAM 12 {ECO:0000313|EMBL:SHM20470.1,
RC ECO:0000313|Proteomes:UP000190911};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; LT670847; SHM20470.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M7GW62; -.
DR STRING; 29571.SAMN05878437_1763; -.
DR InParanoid; A0A1M7GW62; -.
DR OrthoDB; 6500477at2; -.
DR Proteomes; UP000190911; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000190911};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..788
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012409994"
FT TRANSMEM 146..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 528..567
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 569..632
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 666..726
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 749..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 84770 MW; 4AD41DEDB1F54E03 CRC64;
MTPLRLLPKL GAWLCLWLLA AVMLSAPALA QTSPSDAAGA EGDTATYATL ADLLENDQSR
QKLVELLRNQ AADLPEGAVQ QQLPEQLPAQ AAQGSDIAPE DVSLPRQIAE VTSNVVGGVG
TQLGQLLEIA RGLVSGDGAG SFDTGAFVSA TINLGLVIAA TFLLFIACRR LAKPLFTRIS
GWSRRGDYTP VLRLVACVAV AALIDVLIVV LAYVGGNLIA TFAVGQSGDL STRASLFLNA
FLVIELIKAA VRMLFSSRYE GLRLLPISAP EASYWNRWIA RLVGMVGYGQ MVAVPLVNYY
LAASLGQALG TLITVAAFIY AVVVVLKNRL RLRTSINAAA ARSTLAASRI ALQLLARTWH
LLALIYFIGV FVITLLSPVE ALPFVLFATL QTLIAVVVGL LLSSFLSQTI GRRIQLSADM
NRKLPMLEKR LNSYVPNMLR VLRTFILVAV IMVVLNAWYV FDLAAWYASQ QGIALVSKLI
HVVIILIVAL AVWLGLASLI EHKLNPDTGR GEPTARAKTL LSLFRNALII TMITMTGMIV
LAEIGINIGP LIAGAGVLGL AIGFGSQKLV QDVITGVFIQ IENAMNTGDV VTAGGVTGTA
ERFSIRSVGI RDLAGTYHIV PFSSVDTVAN YMREFAYHVG EYRIAYNESI DHAVEQLQVA
FADLQASDEH SHKLLEELTV AGVTSLADSS VNIRVMIMTT PGDQWAVGRA YNRLVKLRFD
DAGIEIPRPH TTLYFGERKD GSAPAANIRV LDSTSVESTG PKRRDDPSRG VQTGQNADYT
KPTDDDVD
//
