ID A0A1M7HT04_9GAMM Unreviewed; 237 AA.
AC A0A1M7HT04;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=tRNA (guanine(46)-N(7))-methyltransferase {ECO:0000256|ARBA:ARBA00011977};
DE EC=2.1.1.33 {ECO:0000256|ARBA:ARBA00011977};
GN ORFNames=SAMN05878437_2321 {ECO:0000313|EMBL:SHM31529.1};
OS Halomonas subglaciescola.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=29571 {ECO:0000313|EMBL:SHM31529.1, ECO:0000313|Proteomes:UP000190911};
RN [1] {ECO:0000313|EMBL:SHM31529.1, ECO:0000313|Proteomes:UP000190911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACAM 12 {ECO:0000313|EMBL:SHM31529.1,
RC ECO:0000313|Proteomes:UP000190911};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the formation of N(7)-methylguanine at position 46
CC (m7G46) in tRNA. {ECO:0000256|ARBA:ARBA00003015}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-
CC methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:42708, Rhea:RHEA-COMP:10188, Rhea:RHEA-COMP:10189,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269,
CC ChEBI:CHEBI:74480; EC=2.1.1.33;
CC Evidence={ECO:0000256|ARBA:ARBA00000142};
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DR EMBL; LT670847; SHM31529.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M7HT04; -.
DR STRING; 29571.SAMN05878437_2321; -.
DR InParanoid; A0A1M7HT04; -.
DR OrthoDB; 9809889at2; -.
DR Proteomes; UP000190911; Chromosome i.
DR GO; GO:0008176; F:tRNA (guanine(46)-N7)-methyltransferase activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase_Trmb.
DR Pfam; PF02390; Methyltransf_4; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51625; SAM_MT_TRMB; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:SHM31529.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000190911};
KW Transferase {ECO:0000313|EMBL:SHM31529.1}.
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 26090 MW; 38F766E8FB6A08F6 CRC64;
MQPPSSSSTN APPPSSRVVV SSQPGPHHDL ARRVSRALAS PLQKPIAEHT QAAFYQAEAW
LVAQNAPLIL DAGCGVGLST RRLAATFADH AVIGVDRSAD RLSRDHGALP DNALLVRADL
VDFWRLALRA GWAPARHYVL YPNPYPKAAQ LKMRWHGHPV LPSLLALGGR LELRTNWRLY
AEEFALAVVQ VTGREATLAQ YNPSGDYLTP FEAKYEQSGQ PLWQLTANLE RAWHLST
//
