ID A0A1M7IHU6_9ACTN Unreviewed; 318 AA.
AC A0A1M7IHU6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Isopenicillin N synthase {ECO:0000313|EMBL:SHM39997.1};
GN ORFNames=SAMN05443668_101490 {ECO:0000313|EMBL:SHM39997.1};
OS Cryptosporangium aurantiacum.
OC Bacteria; Actinomycetota; Actinomycetes; Cryptosporangiales;
OC Cryptosporangiaceae; Cryptosporangium.
OX NCBI_TaxID=134849 {ECO:0000313|EMBL:SHM39997.1, ECO:0000313|Proteomes:UP000184440};
RN [1] {ECO:0000313|EMBL:SHM39997.1, ECO:0000313|Proteomes:UP000184440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46144 {ECO:0000313|EMBL:SHM39997.1,
RC ECO:0000313|Proteomes:UP000184440};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC family. {ECO:0000256|RuleBase:RU003682}.
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DR EMBL; FRCS01000001; SHM39997.1; -; Genomic_DNA.
DR RefSeq; WP_073250961.1; NZ_FRCS01000001.1.
DR AlphaFoldDB; A0A1M7IHU6; -.
DR STRING; 134849.SAMN05443668_101490; -.
DR OrthoDB; 21825at2; -.
DR Proteomes; UP000184440; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR026992; DIOX_N.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR47990; 2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED; 1.
DR PANTHER; PTHR47990:SF258; FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF14226; DIOX_N; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Iron {ECO:0000256|RuleBase:RU003682};
KW Metal-binding {ECO:0000256|RuleBase:RU003682};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003682};
KW Reference proteome {ECO:0000313|Proteomes:UP000184440}.
FT DOMAIN 171..281
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 318 AA; 34471 MW; 0E8DBF4E2AB7D53C CRC64;
MTEPVPSIDL RPWFSGEDRA GVAAQVDAAL QRSGFMLVTG HGVAPELRAA TRGAARAFFA
LPTAVKQQYA ATVGGRGWLP TGVEANGYAE GTETPPDLKE TFAIGADQRV GDPVVDAAWF
LPNVWPAEAP ELHDVLTRYQ AAMRTLADQL LEVCAAALGL PTSFFVPTTD HPTWTLNINW
YPPMGVVGEP EEGQYRIGPH TDFGTLTLLD REYGSGGLQV FTADGEWVDA PYDPEAFTIN
VGDLLARWTG DRWLSARHRV LPPQADAPDE DLVSLVYFYE ANHDAVVEAL EPPIGRAAHP
PVVSGDFIRE RLDAITIA
//
