ID A0A1M7IWU0_9BACT Unreviewed; 133 AA.
AC A0A1M7IWU0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Putative nickel-responsive regulator {ECO:0000256|HAMAP-Rule:MF_00476};
GN ORFNames=SAMN05444266_108113 {ECO:0000313|EMBL:SHM44767.1};
OS Chitinophaga jiangningensis.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Chitinophaga.
OX NCBI_TaxID=1419482 {ECO:0000313|EMBL:SHM44767.1, ECO:0000313|Proteomes:UP000184420};
RN [1] {ECO:0000313|EMBL:SHM44767.1, ECO:0000313|Proteomes:UP000184420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27406 {ECO:0000313|EMBL:SHM44767.1,
RC ECO:0000313|Proteomes:UP000184420};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator. {ECO:0000256|HAMAP-Rule:MF_00476}.
CC -!- COFACTOR:
CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00476};
CC Note=Binds 1 nickel ion per subunit. {ECO:0000256|HAMAP-Rule:MF_00476};
CC -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC {ECO:0000256|HAMAP-Rule:MF_00476}.
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DR EMBL; FRBL01000008; SHM44767.1; -; Genomic_DNA.
DR RefSeq; WP_073084962.1; NZ_FRBL01000008.1.
DR AlphaFoldDB; A0A1M7IWU0; -.
DR STRING; 1419482.SAMN05444266_108113; -.
DR OrthoDB; 9806294at2; -.
DR Proteomes; UP000184420; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR CDD; cd22231; RHH_NikR_HicB-like; 1.
DR Gene3D; 3.30.70.1150; ACT-like. Chain A, domain 2; 1.
DR Gene3D; 1.10.1220.10; Met repressor-like; 1.
DR HAMAP; MF_00476; NikR; 1.
DR InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR InterPro; IPR022988; Ni_resp_reg_NikR.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR PANTHER; PTHR34719; NICKEL-RESPONSIVE REGULATOR; 1.
DR PANTHER; PTHR34719:SF2; NICKEL-RESPONSIVE REGULATOR; 1.
DR Pfam; PF08753; NikR_C; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF47598; Ribbon-helix-helix; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00476};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00476};
KW Nickel {ECO:0000256|HAMAP-Rule:MF_00476};
KW Reference proteome {ECO:0000313|Proteomes:UP000184420};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_00476};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00476}.
FT DOMAIN 55..130
FT /note="Transcription factor NikR nickel binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08753"
FT BINDING 77
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT BINDING 88
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT BINDING 90
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT BINDING 96
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
SQ SEQUENCE 133 AA; 15249 MW; 48E50104EF526C0F CRC64;
MKVVRFGVSV EKNVLELLDN YMEDNQFPNR SQAIRHLIQR IEVEKQWQSD EVVGGSITLL
FDHHKRDLLD KITDIQHDYH DLILCSQHIH LDHDNCMEII AVKGKASLLK QLANALTAVK
GIIHGELSMT KIS
//
