ID A0A1M7MDZ0_9BACT Unreviewed; 1470 AA.
AC A0A1M7MDZ0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SHM88968.1};
GN ORFNames=SAMN04488057_104243 {ECO:0000313|EMBL:SHM88968.1};
OS Cyclobacterium lianum.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Cyclobacterium.
OX NCBI_TaxID=388280 {ECO:0000313|EMBL:SHM88968.1, ECO:0000313|Proteomes:UP000184513};
RN [1] {ECO:0000313|EMBL:SHM88968.1, ECO:0000313|Proteomes:UP000184513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6102 {ECO:0000313|EMBL:SHM88968.1,
RC ECO:0000313|Proteomes:UP000184513};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; FRCY01000004; SHM88968.1; -; Genomic_DNA.
DR RefSeq; WP_073094021.1; NZ_FRCY01000004.1.
DR STRING; 388280.SAMN04488057_104243; -.
DR OrthoDB; 636130at2; -.
DR Proteomes; UP000184513; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184513};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 343..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 939..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 987..1006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1056..1078
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1470 AA; 164066 MW; 25678D8441DE03A0 CRC64;
MINKIISFSI KNKFIVGLLT LALIGVGIYS MSTVNLGSVP DITNNQVQVI TVSPNLATED
IEQFVTYPVE LAMGNLPGVD EIRSISRFGL SVVTIVFEDD MGTYLPRQLV QEKLNELKET
IPEKFGSPSM GPISTGLGQI YEYTIQPQEG YDSLYSPMEL RTIQDWIVKR QLTLLDGVVE
VNSFGGYIKQ YEVAISPDKL NAQNVSISQV YEALARNNVN TGGAYIEKNR MSNFIRGEGL
VRSLDDIRKI VIKTENGIPV TVGDVASKVH FGNQVRYGAF TQDGKEAVGG IIMMLKGSNP
NAVIQNVKER MAEVEKSLPE GLTIYTIIDR SDLISRTTDT VKTNLLEGAL IVIFALVILL
GSVRGGIITA TTIPLSLLFA FILMKQFNVW ANLMSLGAID FGIIIDGAVI IIEGTVYEIQ
KRIRSGKIKF NQGVMDEVAY DAGSTMMSSA FFGQIIILIV FAPILFLTGV EGKMFQPMAY
TFGFAMIGAI ILCLTYVPMM SALFMKPIQN KKNWFGRFER WLERVSDKII GGIQKAYLPL
LKSALRFKAI VIIVAIVLLG TAGFIFSRMG GEFVPQLDEG DIAMQALIRP GSSLSESKEV
SIRIENLLLE SFPEIKTVTA RIGVADIPTD PMPMDIADMY LILEKDKDQW VSAETKDELI
EQIKDKLEMH LTGVNLVFTQ PVELRFNELL EGVREDIAVK LYGEDLEVLS EKVQEMADII
STVPGAGDVN PERTSGLPQM TVRYNRDKIA QYGLDIQKLN EYVSSAFAGG VAGVIFEGEK
RFDLVIRFDE AHRKSIDDLR TLYIDLPDGT QVPIKEVADI SYVPGPMQIS RDNTYRRTYV
GVNTRGRDVE SVVNDIQEKL DAQLELPPGY YITYGGEFEN LERAKSRLAI VVPIALFLIF
VLLYFALQSF SQSIMIYIAI PLAAIGGIFA LWIRDMPFSI SAGVGFIVLF GVAVLNGLVL
INRFNSLKEE GVTSIRERIL TGTKERIRPI MLTATTDIFG FLPMAFSGSA GAEVQRPLAT
VVIGGMLTAT LLTLLVLPVL YTFVEGRSDK RKNLKAPNAN VIIVLIVCGG LFGLPAMANA
QQQGQEKDSL PTITLEQARK RAVESYPKIQ SARLEIESQQ ALKKTAWDFG NTQVFTGKEE
VGNGSDGVYT QIGIQQQQID IFGIAPRLKL QKERVALAEK ALDLSVIELE REVSQAWAMV
YAAKNNYQVY EQLDSVFTDI ERAARIRLET EATSKLEYLA TSNQANQVQI QKEQAYRDYL
SALQRLNLWF ANDTLFTVPD IPATQLDEPL NYVADSLMNH PLLNVSKQRV DVADATIKER
YSQFLPQLQG QYGRQQVDGQ SGFYQYQVGI RIPLFFGPEL GRTQSAKIQR DIAGQNLRQT
QLELNAAYQN QKEQYLKWLN SWNYYRDEAL PLAQEQRSGT ILAYREGAID YVTFLQNIRD
AIRIEVDSWN AFGNYLDSRY QLEYYLKTSN
//
