ID A0A1M7N979_9SPHI Unreviewed; 591 AA.
AC A0A1M7N979;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Phenylalanine-4-hydroxylase {ECO:0000313|EMBL:SHN00100.1};
GN ORFNames=SAMN05216524_104502 {ECO:0000313|EMBL:SHN00100.1};
OS Mucilaginibacter sp. OK098.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1855297 {ECO:0000313|EMBL:SHN00100.1, ECO:0000313|Proteomes:UP000184158};
RN [1] {ECO:0000313|EMBL:SHN00100.1, ECO:0000313|Proteomes:UP000184158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK098 {ECO:0000313|EMBL:SHN00100.1,
RC ECO:0000313|Proteomes:UP000184158};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; FRCM01000004; SHN00100.1; -; Genomic_DNA.
DR RefSeq; WP_073404777.1; NZ_FRCM01000004.1.
DR AlphaFoldDB; A0A1M7N979; -.
DR STRING; 1855297.SAMN05216524_104502; -.
DR OrthoDB; 9780502at2; -.
DR Proteomes; UP000184158; Unassembled WGS sequence.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 1..345
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 132
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 137
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 222
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 591 AA; 66238 MW; 19EF88DEC8C5E29C CRC64;
MSSFNDFGNP QVAALPAHLK QFIVDQHYEH YTPVDHAVWR YVMRQNYSYL KDVAYYPYIP
GLEKAGLSIE KIPSLQEMND ALAKIGWGAV TVDGFIPPAA FMEYQAYRVL VIAADIRQLK
HIEYTPAPDI IHESAGHAPI IADKDYHEYL SYFGSIGAKA MFSAQDFELY EAIRALSILK
EMPDADANEI NKAEELLAHR QENMGEPSEM ALLSRLHWWT VEYGLIGNLA SPKIYGAGLL
SSIGESASCM DSDIKKIPYT IDAINYTYDI TKTQPQLFVT PTFQNLIDVL ETFANTMSFR
KGGVYGLQKA IESKNTCTAV YSSGLQVSGT FTDFKQHNND PVFVKTTGPS ALAVDNRQLK
GHGKDYHKDG FSSPVGKLNG HAMPLENLSV EELNYFGIEQ GKTTELNFES GISVIGEVKE
IITSNCKTQL ITFTNCTVKG KAGELLFDPT WGVYDMAVGE KIASVFCGAA DKGEFLEIAY
KSDTLTHHAA YDNNTIELHK LYQQVRNRRH NGGDFGFLGN VWLMLQKNHH DDWLCALEIL
EILDHEEIEP DLAAEIRSFL EQKAINEPEC KKLINDGFYL IKHPVEQKLV V
//
