ID A0A1M7PSN2_9ACTN Unreviewed; 846 AA.
AC A0A1M7PSN2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN05216499_12567 {ECO:0000313|EMBL:SHN20454.1};
OS Actinacidiphila paucisporea.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Actinacidiphila.
OX NCBI_TaxID=310782 {ECO:0000313|EMBL:SHN20454.1, ECO:0000313|Proteomes:UP000184111};
RN [1] {ECO:0000313|EMBL:SHN20454.1, ECO:0000313|Proteomes:UP000184111}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.2025 {ECO:0000313|EMBL:SHN20454.1,
RC ECO:0000313|Proteomes:UP000184111};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FRBI01000025; SHN20454.1; -; Genomic_DNA.
DR RefSeq; WP_073501886.1; NZ_FRBI01000025.1.
DR AlphaFoldDB; A0A1M7PSN2; -.
DR STRING; 310782.SAMN05216499_12567; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000184111; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SHN20454.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000184111};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 379..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 620..831
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 846 AA; 90363 MW; A8AFCE6BF1A99A29 CRC64;
MARGTLRIYL GAAPGVGKTY AMLSEAHRRV ERGTDLVIGY VEHHHRPRTE VMMHGLEEVA
RREHDYRGSS FTEMDVDAVL RRAPEVALVD ELAHTNVPGS RNAKRWQDVE ELLAAGIDVV
SNVNIQHLES LGDVVEAITG VRQRETVPDE VVRRADQIEL VDMSPQSLRR RMAHGNIYAP
DKVDAALSNY FRPGNLTALR ELALLWTADR VDEYLREYRA EHRISAAWKA RERIVVGLTG
GPEGRTLIRR AARMAAKGSG GEILAVHIVR SEGPVSGSAK ELAVQRTLVE DLGGSFHHVI
GDEVPDALLD FARGADATQI VLGSSRRKTW QYAFGPGVGT TVAREAGDID VHIVSHEHVA
KGRGLPAARG ARLGRSRVVA GWLTGVLGPV LLAVVLTRWH PGPGQATDML LFLTLTVAAA
LVGGLLPALA SAVVGSLLLN YYFTRPTHSF TIAEPENIVA IVIFVLVGAA VASVVDLAAR
RTQQAARLRA EAEILSHLAG SVLRGESSLD ALLERVRETF GMESVVLLER EGEHAPWKCA
AAVGSRPCAR PEDADVEVAV NDRLSLALLG RVLPASDRRV LSAFAAQAAV VLDRKRLADE
AGRARQLAEG NRIRTALLAA VSHDLRTPLA GIKASVSSLR SADVAWSAED EAELLAGIED
GTDRLDHLVG NLLDMSRLQT GTVNPLIREL DLDEVVPMAL GGVPERSVTL DIPETLPMVA
VDPGLLERSV ANVVENAVKY SPPGEAVLVA ASALGDRVEV RVADRGPGVP DSAKEQIFEP
FQRYGDAPRG TGVGLGLAVA RGFAEAMGGT LVAEDTPGGG LTMVLTLRAA AGGRPARPGL
PATATP
//
