ID A0A1M7Q702_9ACTN Unreviewed; 895 AA.
AC A0A1M7Q702;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:SHN25946.1};
GN ORFNames=SAMN05443668_104205 {ECO:0000313|EMBL:SHN25946.1};
OS Cryptosporangium aurantiacum.
OC Bacteria; Actinomycetota; Actinomycetes; Cryptosporangiales;
OC Cryptosporangiaceae; Cryptosporangium.
OX NCBI_TaxID=134849 {ECO:0000313|EMBL:SHN25946.1, ECO:0000313|Proteomes:UP000184440};
RN [1] {ECO:0000313|EMBL:SHN25946.1, ECO:0000313|Proteomes:UP000184440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46144 {ECO:0000313|EMBL:SHN25946.1,
RC ECO:0000313|Proteomes:UP000184440};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FRCS01000004; SHN25946.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M7Q702; -.
DR STRING; 134849.SAMN05443668_104205; -.
DR Proteomes; UP000184440; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184440};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 653..846
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 89019 MW; C92C2C4706C26C7E CRC64;
MRSGERRAPG GAPAPGGAPA PGGAAQVAAP AAAPSREAAA GAGRPPVDLR LAGVALGAWI
TVWWCLGHGP GAAAWAAAGA ALVAAIAAAT GTTLLRAADA AARAGGATVS AAGVAVRAGR
AAPVRGGPGA RGRVARPAWG RAVGVGGASG ARGRVARPVW GRAVGVGGLG QGRGIWVGGL
ALGIAGVALG AATGAVAALP RLVERDTGPL ARAVVRSGTV SVRLVVRDDP RPSAVRRGGV
PLWVVPASVE ELTADGVRHA TGGRILVLGR DAGWEGLLPG QAVAVGGRLL APQRRDLTAA
VLSTTEAPQR LGEPPWLQRA AGDLREGLRD ACAPLPDKPG GLLPGLVVGD TSELDPGVEE
AFRQTGMTHL TAVSGANLAI MAGLVLVTLR GVRVSPGWSA ALAAVAVAGF VVLARPSPSV
VRAAAMCGLG LLALALGRPR AAVPALCVSV VALVLGDPAL AAAPGFALSV AATAGLLLLA
PVWSAAMQRR HVPVPAADAL AVPAAAQAAC APLLAALTGT VSLTAIPANL LAAPAVAPAT
VLGLLAAVAA PVAEPVAIGM AWLGQWPARW LVVVAERGAT VPDGLVPWPD GAFGGWALAA
LLAGGAFLAR WRLPRRLLAV VTAAVVVAVL PIRVVAPGWP PPGWALVACD VGQGDAVVLR
AGAGSAVVVD VGPDPAPVDG CLRRLGIHQV PLLVLSHLHL DHIGGLDGAL RGRTVGVIAL
GPYAEPAEGA AAVTRSARRH GVRIVQLTAG RELIAGAVAL RVLGPLRVLR GTRSDPNNNS
LILRADVASV SVLLPGDAEH DAERALLDAG VPLAVDVLKV PHHGSAWSEH AFLDAAAARV
AVIPVGADNE YGHPDPGVLA YLARRGARVL RTDQSGDLAV VAHRDGSLST AARPP
//
