ID A0A1M7Q769_9BACT Unreviewed; 768 AA.
AC A0A1M7Q769;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Multicomponent Na+:H+ antiporter subunit A {ECO:0000313|EMBL:SHN26155.1};
GN ORFNames=SAMN04488057_114110 {ECO:0000313|EMBL:SHN26155.1};
OS Cyclobacterium lianum.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Cyclobacterium.
OX NCBI_TaxID=388280 {ECO:0000313|EMBL:SHN26155.1, ECO:0000313|Proteomes:UP000184513};
RN [1] {ECO:0000313|EMBL:SHN26155.1, ECO:0000313|Proteomes:UP000184513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6102 {ECO:0000313|EMBL:SHN26155.1,
RC ECO:0000313|Proteomes:UP000184513};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; FRCY01000014; SHN26155.1; -; Genomic_DNA.
DR RefSeq; WP_073096746.1; NZ_FRCY01000014.1.
DR AlphaFoldDB; A0A1M7Q769; -.
DR STRING; 388280.SAMN04488057_114110; -.
DR OrthoDB; 9807568at2; -.
DR Proteomes; UP000184513; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184513};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 647..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..108
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 124..412
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 605..670
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 680..760
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
SQ SEQUENCE 768 AA; 84168 MW; 400FFEE69CD8E7E5 CRC64;
MLIAVISGFV FALLVPWIMA QSKSKTTIWT ALLPLAIFTF FLLHLPEIQN DGSVKVSYSW
VPSIGINLDF YLDGLSMLFV LLISGIGSLV FVYTSTYLKG HPFLDRFYAY LSMFMASMLG
LVLSDNIYTL FIFWELTSIS SFFLIGFNND NQASRRSALT ALSVTGIGGL FLLAAMVGLG
HTAQVNQISE MSSLSEIIQA DNLYGWIIVF LFLAAFTKSA QFPFHFWLPG AMKAPTPVST
YLHSATMVKA GIYLLARFSP VLGGHEWWNG TLITVGAITM VYAAIHALFR LDLKGILAYS
TISALGILVF LIGLGTSAAF LAAAVFILVH ALYKATLFLV TGIIDHETGT RDISQLGGLN
KVMLPVGVAA LLAAISNAGI PPSFGFVGKD LIYDATLGMG DLAWILTTLA VITNIALLFA
GFLAGIKPFF GKLPERFAKL HLPGPAMYIP PLILGVLCMF FGLLPFLLES SLIQPVVSSF
TETLPDIHLK LWHGFNLILL LSAVTIGAGT ALYFIIKPSE KLLAMVSRFE RISPESIAML
ASGGFTRFSS GWTKFFQNGY LRYYLITILS FLSLLLAYRL FTGVTLYLDT SSMTAVTFYE
VVVLVIMAVA ILFTVFSKSR LVAVASMGVV GYSFCLIFLF YSAPDLAMTQ FSIDTLTVIL
FVLVLYNLPK YLKLSETRDR IRDGLLSLFF GALISLLTIE VMNESVDKET SQYYAENAYV
LGKGKNVVNV ILVDFRGFDT MVEITVLAIA AIGVFGLLKL HLRSTEKE
//
